Method and system for obtaining a first signal for analysis to characterize at least one periodic component thereof

• US 8,938,097 B2
• Filed: 02/04/2014
• Issued: 01/20/2015
• Est. Priority Date: 10/06/2009
• Status: Active Grant

• Current Assignee: Koninklijke Philips N.V.
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Kirenko, Ihor Olehovych, Jeanne, Vincent, De Haan, Gerard, Van Leest, Adriaan Johan
• Primary Examiner(s): Mehta, Bhavesh
• Assistant Examiner(s): Harandi, Siamak
• Application Number:
  US14/172,519
• Publication Number:
  US 20140153800A1
• Time in Patent Office: 350 Days
• Field of Search: None
• US Class Current: 382/103
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: G06T 2207/30076 Plethysmography
• CPC Class Codes: G06T 5/50 using two or more images, e.g. averaging or subtraction
• CPC Class Codes: G06T 7/0012 Biomedical image inspection

Abstract

A method of facilitating obtaining a first signal, for analysis to characterize at least one periodic component, includes obtaining two second signals representative of intensities of electromagnetic radiation. The first signal is at least derivable from an output signal obtainable by applying a transformation to the second signals such that any value of the output signal is based on values from each respective second signal at corresponding points in time. The method further includes obtaining a value of a variable determining influences of components of respective second signals on the output signal when the signals corresponding to the second signals are captured and the transformation is applied, by (i) analyzing the first, second and/or the output signals to select a value of a parameter corresponding to a respective one of the variables; or (ii) calculating values of at least one time-varying factor corresponding to a respective one of the variables.

Claims

1. A method for remote photoplethysmography facilitating obtaining a first signal for analysis to characterize at least one periodic component thereof, the at least one periodic component corresponding to a biological phenomenon in a living subject, the method including acts of:

obtaining at least two second signals representative of intensities of captured electromagnetic radiation, each corresponding to a respective different radiation frequency range,

the first signal being derivable from an output signal obtainable by applying a transformation to the second signals such that any value of the output signal is based on values from each respective second signal at corresponding points in time,

obtaining at least one value of at least one variable determining influences of at least components of respective second signals on the output signal by at least one of;

(i) analyzing at least one of the second signals, the output signal, and the first signal, and

using the analysis to select at least one value of at least one parameter corresponding to a respective one of the variables; and

(ii) calculating values of at least one time-varying factor corresponding to a respective one of the variables, each factor value based on at least one second signal value, and applying each factor in an operation in at least one of a number of parallel sequences of operations comprising at least one such operation and taking a signal corresponding to a respective one of the second signals as input.

2. The method according to claim 1, wherein the analysis of at least one of the second signals, the output signal and the first signal is used to select at least one value of at least one parameter determining influences of at least components of respective second signals on the output signal so as to maximize a relative signal strength in a limited part of a spectrum of the first signal.

3. The method according to claim 1, wherein the transformation includes at least one parameterized operation, and wherein the analysis of at least one of the second signals, the output signal and a first signal is used to select values of at least one parameter of the operation.

4. The method according to claim 3, wherein the operation is an operation taking at least two inputs based in different ways on the second signals.

5. The method according to claim 3, wherein the transformation includes an operation carried out in parallel on respective input signals using at least one parameter value specific to fewer than all of the input signals.

6. The method according to claim 3, wherein the transformation includes at least one parameterized non-linear operation, and wherein the analysis of at least one of the second signals, an output signal obtained by applying the transformation to the second signals and a first signal derived from the output signal is used to select values of at least one parameter of the operation.

7. The method according to claim 1, wherein the transformation includes an operation carried out in parallel on respective input signals, each a different linear combination of second signals with at least one coefficient differing from zero, the operation comprising taking a logarithm of the input signal.

8. The method according to claim 1, wherein the analysis includes carrying out a principal component analysis on data sets respectively based on a plurality of second signals.

9. The method according to claim 1, wherein at least one of the second signals, an output signal obtained by applying the transformation to the second signals and a first signal derived from the output signal is analyzed and the analysis is used to select at least one value of at least one parameter determining influences of at least components or respective second signals on the output signal when the signals corresponding to the second signals are captured and the transformation is applied, the method further including causing the selected values of the at least one parameter to be loaded into a system comprising:

an interface for obtaining at least two second signals representative of intensities of captured electromagnetic radiation, each corresponding to a respective different radiation frequency range; and

a signal processing system for applying a transformation to the second signals to obtain an output signal from which the first signal is at least derivable, any value of the output signal being based on values from each respective second signal at a common point in time,

wherein the system is arranged to cause influences of respective second signals on the output signal to be determined at least partly in accordance with the loaded values of the at least one parameter.

10. The method according to claim 1, wherein the analysis of at least one of the second signals, an output signal obtained by applying the transformation to the second signals and a first signal derived from the output signal and the selection of at least one parameter value is carried out continually whilst processing the second signals to obtain the first signal.

11. The method according to claim 1, wherein the at least one time-varying factor includes a factor obtainable by calculating a linear combination of corresponding values from each of at least one of the second signals, and wherein the same value of that factor is used in each of the parallel sequences of operations.

12. The method according to claim 1, wherein, for at least one of the factors, separate values at corresponding associated points in time are calculated for each of the parallel sequences, each obtained from multiple values of the second signal taken as input by the sequence concerned, the multiple values being associated with respective points in time spanning an interval including the point in time associated with the factor value.

13. A system for remote photoplethysmography for obtaining a first signal for analysis to characterize at least one periodic component thereof, the at least one periodic component corresponding to a biological phenomenon in a living subject, the system including:

an interface configured to obtain at least two second signals representative of intensities of captured electromagnetic radiation, each corresponding to a respective different radiation frequency range,

the first signal being derivable from an output signal obtainable by applying a transformation to the second signals such that any value of the output signal is based on values from each respective second signal at corresponding points in time; and

a processor is configured to obtain at least one value of at least one variable determining influences of at least components of respective second signals on the output signal by at least one of;

(i) analyzing at least one of the second signals, the output signal and the first signal, and

using the analysis to select at least one value of at least one parameter corresponding to a respective one of the variables and determining influences of at least components of respective second signals on the output signal; and

(ii) calculating values of at least one time-varying factor corresponding to a respective one of the variables, each factor value based on at least one second signal value, and applying each factor in an operation in at least one of a number of parallel sequences of operations comprising at least one such operation and taking a signal corresponding to a respective one of the second signals as input.

14. A system for remote photoplethysmography for obtaining a first signal for analysis to characterize at least one periodic component thereof, the at least one periodic component corresponding to a biological phenomenon in a living subject, the system including:

means for obtaining at least two second signals representative of intensities of captured electromagnetic radiation, each corresponding to a respective different radiation frequency range,

the first signal being derivable from an output signal obtainable by applying a transformation to the second signals such that any value of the output signal is based on values from each respective second signal at corresponding points in time,

means for obtaining at least one value of at least one variable determining influences of at least components of respective second signals on the output signal by at least one of;

(i) analyzing at least one of the second signals, the output signal, and the first signal, and

using the analysis to select at least one value of at least one parameter corresponding to a respective one of the variables; and

(ii) calculating values of at least one time-varying factor corresponding to a respective one of the variables, each factor value based on at least one second signal value, and applying each factor in an operation in at least one of a number of parallel sequences of operations comprising at least one such operation and taking a signal corresponding to a respective one of the second signals as input.

15. A method for characterizing periodic component of a processed signal comprising acts of:

obtaining at least two signals representative of intensities of captured electromagnetic radiation, each corresponding to a respective different radiation frequency range;

analyzing the at least two signals by applying a transformation to the at least two signals to form a transformed signal such that any value of the transformed signals is based on values from each of the at least two signals at corresponding points in time;

combining the transformed signals into an output signal; and

obtaining values of variables determining influences of components of the second signals on the output signal by at least one of;

selecting at least one value of at least one parameter corresponding to a respective one of the variables; and

calculating values of at least one time-varying factor corresponding to a respective one of the variables, and performing a normalization of the second signals using the calculated values.