Blow-molded syringe for use with injectors

• US 8,939,940 B2
• Filed: 06/07/2010
• Issued: 01/27/2015
• Est. Priority Date: 08/03/2006
• Status: Active Grant

• Current Assignee: Bayer Healthcare LLC (Bayer AG)
• Original Assignee: Bayer Medical Care Inc. (Bayer AG)
• Inventors: Haury, John A., Rhinehart, Edward J., Belcher, Samuel L.
• Primary Examiner(s): Stigell, Theodore
• Assistant Examiner(s): HAYMAN, IMANI N
• Application Number:
  US12/794,990
• Publication Number:
  US 20100241085A1
• Time in Patent Office: 1,695 Days
• Field of Search: 604/187, 604/216, 604/218, 604/72, 604/146, 604/181, 264/532, 264/537, 264/524, 264/535
• US Class Current: 604/187
• CPC Class Codes: A61M 2207/10 Device therefor
• CPC Class Codes: A61M 5/007 for contrast media
• CPC Class Codes: A61M 5/14546 Front-loading type injectors
• CPC Class Codes: A61M 5/14566 with a replaceable reservoir for receiving a piston rod of the pump
• CPC Class Codes: A61M 5/3129 Syringe barrels A61M5/3205 and A61M5/50 take precedence
• CPC Class Codes: B29B 11/08 Injection moulding
• CPC Class Codes: B29B 11/10 Extrusion moulding
• CPC Class Codes: B29B 11/14 characterised by structure or composition
• CPC Class Codes: B29C 2949/0715 the preform having one end closed
• CPC Class Codes: B29C 2949/072 having variable wall thickness
• CPC Class Codes: B29C 2949/073 having variable diameter
• CPC Class Codes: B29C 2949/0762 Conical
• CPC Class Codes: B29C 2949/0767 the shape allowing stacking or nesting
• CPC Class Codes: B29C 2949/077 characterised by the neck
• CPC Class Codes: B29C 2949/0776 not containing threads
• CPC Class Codes: B29C 2949/078 characterised by the bottom
• CPC Class Codes: B29C 2949/3008 at neck portion
• CPC Class Codes: B29C 2949/3012 at flange portion
• CPC Class Codes: B29C 2949/3016 at body portion
• CPC Class Codes: B29C 2949/302 at bottom portion
• CPC Class Codes: B29C 2949/3026 : having two or more components
• CPC Class Codes: B29C 2949/3028 : having three or more components
• CPC Class Codes: B29C 2949/3032 : having components being injected
• CPC Class Codes: B29C 2949/3034 : having two or more components being injected
• CPC Class Codes: B29C 2949/3036 : having three or more components being injected
• CPC Class Codes: B29C 2949/3042 : having two or more components being extruded
• CPC Class Codes: B29C 2949/3044 : having three or more components being extruded
• CPC Class Codes: B29C 49/04 : Extrusion blow-moulding
• CPC Class Codes: B29C 49/06 : Injection blow-moulding
• CPC Class Codes: B29C 49/071 : Preforms or parisons characterised by their configuration, e.g. geometry, dimensions or physical properties
• CPC Class Codes: B29C 49/12 : Stretching rods
• CPC Class Codes: B29C 49/22 : using multilayered preforms or parisons
• CPC Class Codes: B29K 2023/086 : EVOH, i.e. ethylene vinyl alcohol copolymer
• CPC Class Codes: B29K 2023/12 : PP, i.e. polypropylene
• CPC Class Codes: B29K 2025/00 : Use of polymers of vinyl-aromatic compounds or derivatives thereof as moulding material
• CPC Class Codes: B29K 2027/08 : PVDC, i.e. polyvinylidene chloride
• CPC Class Codes: B29K 2067/00 : Use of polyesters or derivatives thereof, as moulding material
• CPC Class Codes: B29K 2077/00 : Use of PA, i.e. polyamides, e.g. polyesteramides or derivatives thereof, as moulding material
• CPC Class Codes: B29L 2031/7544 : Injection needles, syringes
• CPC Class Codes: Y10T 428/1352 : Polymer or resin containing [i.e., natural or synthetic]
• CPC Class Codes: Y10T 428/1379 : Contains vapor or gas barrier, polymer derived from vinyl chloride or vinylidene chloride, or polymer containing a vinyl alcohol unit

Abstract

A syringe for use in the pressurized injection of a fluid. The syringe includes a syringe barrel composed of a polymeric material having undergone expansion via blow molding, and an injection molded attachment mechanism which is integral with the syringe barrel and is located at the proximal end of the syringe barrel. The syringe barrel has a consistent wall thickness and is capable of withstanding pressures of at least 1200 psi. The syringe barrel includes a biaxial stretch sidewall as a result of the blow molding process while the attachment mechanism remains essentially unchanged by the blow molding process. The polymeric material can be, for example, polyethyleneterephthalate, cyclic olefin polymer, polypropylene, polystyrene, polyvinylidene chloride, polyethylene naphthalate and/or nylon.

Claims

1. A syringe for use in a pressurized injection of a fluid, the syringe comprising:

a blow-molded syringe barrel formed of a polymeric material, the syringe barrel having a consistent wall thickness and capable of withstanding pressures of at least 1200 psi and formed by a blow-molding process; and

an injection molded attachment mechanism integral with the syringe barrel and located at a proximal end of the syringe barrel,

wherein the syringe barrel comprises a biaxial stretch sidewall as a result of the blow-molding process while the attachment mechanism remains essentially unchanged as a result of the blow-molding process.

2. The syringe of claim 1, wherein the biaxial stretch sidewall of the syringe barrel comprises an inner diameter that does not vary by greater than 0.01 inches.

3. The syringe of claim 1, wherein the biaxial stretch sidewall of the syringe barrel comprises an inner diameter that does not vary by greater than 0.007 inches.

4. The syringe of claim 1, wherein the biaxial stretch sidewall of the syringe barrel comprises an inner diameter that does not vary by greater than 0.004 inches.

5. The syringe of claim 1, wherein the polymeric material is selected from the group consisting of polyethyleneterephthalate, cyclic olefin polymer, polypropylene, polystyrene, polyvinylidene chloride, polyethylene naphthalate, nylon, and combinations thereof.

6. The syringe of claim 1, wherein the syringe barrel comprises a first layer of a first polymeric material and at least a second layer of a second polymeric material, different from the first polymeric material.

7. The syringe of claim 1, wherein the syringe barrel has a consistent wall thickness of less than 0.05 inches.

8. The syringe of claim 1, wherein the syringe barrel has a consistent wall thickness of less than 0.07 inches.

15. The syringe of claim 6, wherein the first polymeric material and the second polymeric material are independently selected from the group consisting of polyethyleneterephthalate, cyclic olefin polymer, polypropylene, polystyrene, polyvinylidene chloride, polyethylene naphthalate, nylon, and combinations thereof.

9. A syringe comprising:

a blow-molded syringe barrel formed of a polymeric material;

an outlet section integrally formed with the syringe barrel at a distal end of the syringe barrel;

an injection molded attachment mechanism integrally formed at a proximal end of the syringe barrel; and

a removable closure integrally molded with the outlet section at a distal end of the outlet section during an injection molding process,

wherein the syringe barrel comprises a biaxial stretch sidewall as a result of the blow-molding process while the attachment mechanism remains essentially unchanged as a result of the blow-molding process.

10. The syringe of claim 9, wherein the removable closure is removably connected to the outlet section via a wall section of reduced thickness.

11. A syringe comprising:

a blow-molded syringe barrel formed of a polymeric material;

an outlet section integrally formed on a distal end of the syringe barrel;

an injection molded attachment mechanism integrally formed with a proximal end of the syringe barrel; and

a removable closure integral with the proximal end of the syringe barrel and formed during the blow-molding process,

wherein the syringe barrel comprises a biaxial stretch sidewall as a result of the blow-molding process while the attachment mechanism remains essentially unchanged as a result of the blow-molding process.

12. The syringe of claim 11, wherein the removable closure comprises a sealing member that forms a seal with an inner wall of the syringe barrel.

13. The syringe of claim 11, wherein the removable closure comprises a flange that forms a wiper seal with an inner wall of the syringe barrel.

14. A syringe comprising:

a blow-molded syringe barrel formed of a polymeric material and comprising a side wall having a first layer of a first polymeric material extending radially inward from a second layer of a second polymeric material, wherein the first layer has a greater lubricity than the second layer and wherein at least one of the first layer or the second layer is capable of withstanding pressures of at least 1200 psi; and

an injection molded attachment mechanism integrally formed with a proximal end of the syringe barrel,

wherein the side wall of the syringe barrel comprises a biaxial stretch orientation as a result of the blow-molding process while the attachment mechanism remains essentially unchanged as a result of the blow-molding process.

16. The syringe of claim 14, wherein the first polymeric material is selected from the group consisting of polyethyleneterephthalate, cyclic olefin polymer, polypropylene, polystyrene, polyvinylidene chloride, polyethylene naphthalate, and nylon.

17. The syringe of claim 14, wherein the second layer has better barrier properties than the first layer.

18. The syringe of claim 14, further comprising a tie layer between the first layer and the second layer.

19. The syringe of claim 14, wherein the second polymeric material is selected from the group consisting of nylon, ethylene vinyl alcohol copolymer (EVOH), and polycarbonate.

20. The syringe of claim 14, wherein at least one of the first layer or the second layer has a thickness of less than 0.07 inches.