Dose dividing delivery device

• US 8,939,959 B2
• Filed: 06/20/2013
• Issued: 01/27/2015
• Est. Priority Date: 01/30/2008
• Status: Active Grant

• Current Assignee: Becton, Dickinson & Co
• Original Assignee: Becton, Dickinson & Co
• Inventors: Baney, Bruno, May, Colin, Dupuis, Patrick, Perot, Frederic
• Primary Examiner(s): Sirmons, Kevin C
• Assistant Examiner(s): PATEL, SHEFALI DILIP
• Application Number:
  US13/922,779
• Publication Number:
  US 20130289493A1
• Time in Patent Office: 586 Days
• Field of Search: 604/506, 604/181, 604/187, 604/207, 604/208, 604/209, 604/210, 604/211, 604/218, 604/500, 604/220, 604/224
• US Class Current: 604/506
• CPC Class Codes: A61M 5/3134 characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula
• CPC Class Codes: A61M 5/31526 by means of stepwise axial movements, e.g. ratchet mechanisms or detents
• CPC Class Codes: A61M 5/31528 by means of rotational movements, e.g. screw-thread mechanisms
• CPC Class Codes: A61M 5/31595 Pre-defined multi-dose administration by repeated overcoming of means blocking the free advancing movement of piston rod, e.g. by tearing or de-blocking
• CPC Class Codes: A61M 5/3243 being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel devices for protecting guide needles in combination with catheters A61M25/0612
• CPC Class Codes: A61M 5/3293 characterised by features of the needle hub

Abstract

A simple method and device enabling a unit dose from a reservoir is provided. The dose is drawn into the reservoir and is then expelled from the device by depressing a plunger. The plunger has features which divide the dose into discrete intervals. As the plunger is moved during delivery, the features on the plunger and features connected to a barrel interact to provide for intermittent stops to the delivery. Other aspects of the device provide for reduced dead space, safety and selective interconnection with other devices. Thus, the device divides the dose.

Claims

1. A multiple dose injection device comprising:

a fluid conduit;

a barrel having a bore, a distal end, and a proximal end wherein the fluid conduit is located at the distal end of the barrel, in fluid communication with the bore and the proximal end of the barrel is adapted to receive a stopper;

a plunger having a distal end and a proximal end and a longitudinal axis wherein the stopper is connected to the distal end of the plunger and movable within the barrel, and the plunger has at least one continuous track formed between the distal and proximal ends of the plunger wherein the at least one continuous track further comprises at least one of each of the following;

a first rest position,

a stop position, having a proximal abutment,

a second rest position,

a camming portion which is skewed to the longitudinal axis of the plunger and formed between the first rest position and the stop position;

a reset portion substantially perpendicular to the axis of the plunger and formed between the stop position and the second rest position; and

,

a slider having a follower movable substantially perpendicular to the axis of the plunger, the slider having a user-pressable portion;

wherein when a portion of the plunger is depressed by a user, the follower moves with respect to the plunger along the camming portion of the at least one continuous track, thereby causing radial motion of the follower and movement of the follower to the stop position at which position a plunger distal movement is prevented by contact of the follower to the proximal abutment, wherein the user may apply a biasing force to the user-pressable portion of the slider, thereby moving the follower along the reset portion to the second rest position.

2. The device as set forth in claim 1 wherein the follower is movable from an initial position wherein the follower is located outside of the at least one continuous track and does not interfere with the plunger movement, to a first position wherein the follower is located within the at least one continuous track.

3. The device as set forth in claim 1 wherein a pattern of the first rest position, stop position, and second rest position are repeated along the plunger at an axial distance between corresponding positions, wherein said axial distance multiplied by a cross sectional area of the bore is a unit volume which comprises a unit dose.

4. The device as set forth in claim 3 wherein the unit dose is a plurality of unit doses and all unit doses are substantially equal.

5. The device as set forth in claim 3 wherein the unit dose is a plurality of unit doses and all unit doses are of varying dosages.

6. The device as set forth in claim 1 further comprising a clip which engages a flange on the barrel and the slider is slidably engaged to the clip.

7. The device as set forth in claim 6 the clip further comprising a plunger guiding portion.

8. The device as set forth in claim 6 wherein the clip and slider are integrally formed with a slidable relationship.

9. The device as set forth in claim 1 wherein the at least one continuous track further comprises two tracks, located on opposing sides of the plunger.

10. The device as set forth in claim 1 wherein the at least one continuous track is a helical track around a circumference of the plunger.

11. The device as set forth in claim 1 wherein the follower is mounted on a deflectable beam.

12. The device as set forth in claim 11 wherein the reset portion further comprises a detent tab located in the at least one continuous track which deflects the follower.

13. The device as set forth in claim 12 wherein the deflection creates an audible sound, thereby providing feedback to the user.

14. The device as set forth in claim 11 wherein the reset portion further comprises a deflectable detent tab located in the at least one continuous track.

15. The device as set forth in claim 1 wherein the follower is elastically deformed in use.

16. The device as set forth in claim 1 wherein the fluid conduit further comprises a detachable needle assembly having a hub, attachable to the distal end of the barrel and a needle inserted into the hub.

17. The device as set forth in claim 16 wherein the hub further comprises a proximal opening adapted to receive an elongated luer tip located at the distal end of the barrel and is adapted to prevent effective use of a standard luer tipped barrel.

18. The device as set forth in claim 1 further comprising a restrictor pin within the fluid conduit thereby reducing dead space.

19. The device as set forth in claim 1 further comprising a hub engaged to the barrel having a needle cover removably attached to said hub.

20. The device as set forth in claim 19 further comprising a shield which is slidably engaged to the hub.

21. A multiple dose injection device comprising:

a fluid conduit;

a barrel having a bore, a distal end, and a proximal end wherein the fluid conduit is located at the distal end of the barrel, in fluid communication with the bore and the proximal end of the barrel is adapted to receive a stopper;

a plunger having a distal end and a proximal end and a longitudinal axis wherein the stopper is connected to the distal end of the plunger and movable within the barrel, and the plunger has at least one continuous track formed between the distal and proximal ends of the plunger wherein the at least one continuous track further comprises at least one of each of the following;

a first rest position,

a stop position, having a proximal abutment,

a second rest position,

a capturing portion formed between the first rest position and the stop position;

a reset portion substantially perpendicular to the axis of the plunger and formed between the stop position and the second rest position; and

,

a slider having a follower movable substantially perpendicular to the axis of the plunger, the slider having a user-pressable portion;

wherein the follower is biased toward the stop position, thereby radially biasing the follower in the capturing portion to the stop position at which position a plunger distal movement is prevented by contact of the follower to the proximal abutment, wherein a user may apply a reverse biasing force to the user-pressable portion of the slider, thereby moving the follower along the reset portion to the second rest position.

22. The device as set forth in claim 21 wherein the follower is movable from an initial position wherein the follower is located outside of the at least one continuous track and does not interfere with the plunger movement, to a first position wherein the follower is located within the at least one continuous track.

23. The device as set forth in claim 21 wherein a pattern of the first rest position, stop position, and second rest position are repeated along the plunger at an axial distance between corresponding positions, wherein said axial distance multiplied by a cross sectional area of the bore is a unit volume which comprises a unit dose.

24. The device as set forth in claim 23 wherein the unit dose is a plurality of unit doses and all unit doses are substantially equal.

25. The device as set forth in claim 23 wherein the unit dose is a plurality of unit doses and all unit doses are of varying dosages.

26. The device as set forth in claim 21 further comprising a clip which engages a flange on the barrel and wherein the clip and the slider are integrally formed with a slidable relationship therebetween.

27. The device as set forth in claim 26 further comprising integrated leaf springs which are integrally molded.

28. The device as set forth in claim 21 wherein the at least one continuous track further comprises two tracks, located on opposing sides of the plunger.

29. The device as set forth in claim 21 wherein the follower is mounted on a deflectable beam.

30. The device as set forth in claim 29 wherein a deflection of said deflectable beam creates an audible sound, thereby providing feedback to the user.

31. The device as set forth in claim 21 wherein the fluid conduit further comprises a detachable needle assembly having a hub, attachable to the distal end of the barrel and a needle inserted into the hub.

32. A method of performing a multiple dose delivery comprising:

providing a device comprising a fluid conduit;

a barrel having a bore, a distal end, and a proximal end wherein the fluid conduit is located at the distal end of the barrel, in fluid communication with the bore and the proximal end of the barrel is adapted to receive a stopper;

a plunger connected to the stopper and movable within the barrel, thereby forming a reservoir, the plunger having a longitudinal axis and at least one continuous track formed between a distal end of the plunger and a proximal end of the plunger wherein the at least one continuous track further comprises at least one of each of the following;

a first rest position,

a stop position, having a proximal abutment,

a second rest position,

a camming portion not parallel to the longitudinal axis of the plunger and formed between the first rest position and the stop position;

a reset portion substantially perpendicular to the axis of the plunger and formed between the stop position and the second rest position; and

,

a slider having a follower and a user depressable portion;

filling the reservoir of the device with a fluid;

moving the slider from an initial position wherein the follower is located outside of the at least one continuous track and does not interfere with plunger movement, to a first position wherein the follower is located within the at least one continuous track;

depressing a portion of the plunger to dispense a portion of the fluid through the fluid conduit and thereby moving the follower with respect to the plunger along the camming portion of the at least one continuous track, thereby causing radial motion of the follower and movement of the follower to the stop position wherein a plunger distal movement is prevented by contact of the follower to the proximal abutment;

applying a biasing force to the user-pressable portion of the slider, thereby moving the follower along the reset portion to the second rest position which coincides with the first rest position; and

,

repeating the depressing and applying steps until all the fluid is dispensed from the reservoir.