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Continuous matrix with osteoconductive particles dispersed therein, method of forming thereof, and method of regenerating bone therewith

  • US 8,940,317 B2
  • Filed: 12/20/2012
  • Issued: 01/27/2015
  • Est. Priority Date: 12/23/2011
  • Status: Active Grant
First Claim
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1. A method of preparing a bone void filler composition, the method comprising:

  • combining particles of a porous, osteoconductive material with a solution of a polypeptide to form a slurry; and

    adding to the slurry a second polymer under conditions such that the polypeptide crosslinks with the second polymer to form a continuous matrix having the particles of the osteoconductive material dispersed therein;

    wherein before said adding step, at least a portion of the pores in the particles of the osteoconductive material have a biocompatible material adsorbed therein.

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