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Methods for modulating de novo hepatic lipogenesis by modulating XBP-1 activity

  • US 8,940,479 B2
  • Filed: 01/14/2009
  • Issued: 01/27/2015
  • Est. Priority Date: 01/14/2008
  • Status: Active Grant
First Claim
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1. A method of treating hyperlipidemia comprising administering a nucleic acid molecule that downmodulates XBP-1 gene expression to a subject having hyperlipidemia in an amount sufficient to downmodulate de novo hepatic lipogenesis, to thereby treat hyperlipidemia in the subject.

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