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Optical detector for use in therapy

  • US 8,940,522 B2
  • Filed: 08/22/2011
  • Issued: 01/27/2015
  • Est. Priority Date: 04/25/2003
  • Status: Active Grant
First Claim
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1. A method of delivering a therapy using an implantable medical device, comprising:

  • presenting a tagged substrate into a bodily fluid, wherein the bodily fluid is blood, wherein the bodily fluid contains an enzyme and a protein substrate, and wherein presenting the tagged substrate to the bodily fluid comprises controlling a substrate pump to present the tagged substrate to the blood via a catheter with a distal end located in a blood vessel of a patient, and further wherein the tagged substrate is tagged with at least two fluorescent dyes;

    emitting energy at a first wavelength into the bodily fluid that contains the enzyme and the protein substrate, and into which the substrate tagged with the at least two fluorescent dyes has been presented;

    detecting energy emitted by a first one of the dyes at a second wavelength based on fluorescent resonant energy transfer from a second one of the dyes in response to the emitted energy at the first wavelength; and

    providing a therapy device comprising a therapy pump configured to deliver a therapy based on the detected energy.

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