Sensor
First Claim
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1. A process for producing a Reactive Oxygen Species (ROS)-quenching analyte-permeable membrane suitable for use in an optical sensor for detecting and/or quantifying the amount of analyte in a sample comprising:
- a. contacting a polypropylene hollow fibre membrane with a ROS-quenching precursor and a reducing agent;
b. reducing the ROS-quenching precursor within pores of the polypropylene hollow fibre membrane to form a ROS-quenching agent within the pores of the polypropylene hollow fibre membrane; and
optionally repeating steps (a) and (b).
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Abstract
A sensor for detecting and/or quantifying the amount of analyte in a sample, the sensor including:
- a sensing region; and
- a barrier layer including a reactive oxygen species (ROS)-quenching, analyte-permeable membrane having an ROS-quenching agent adsorbed to the membrane;
- wherein the sensor is adapted so that the sample enters the sensing region of the sensor through the barrier layer.
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Citations
20 Claims
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1. A process for producing a Reactive Oxygen Species (ROS)-quenching analyte-permeable membrane suitable for use in an optical sensor for detecting and/or quantifying the amount of analyte in a sample comprising:
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a. contacting a polypropylene hollow fibre membrane with a ROS-quenching precursor and a reducing agent; b. reducing the ROS-quenching precursor within pores of the polypropylene hollow fibre membrane to form a ROS-quenching agent within the pores of the polypropylene hollow fibre membrane; and optionally repeating steps (a) and (b). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A process for producing a Reactive Oxygen Species (ROS)-quenching analyte-permeable membrane on a sensor for detecting and/or quantifying the amount of analyte in a sample comprising:
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(a) contacting a polypropylene hollow fibre membrane with a ROS-quenching precursor and a reducing agent; (b) reducing the ROS-quenching precursor within pores of the polypropylene hollow fibre membrane to form a ROS-quenching agent within the pores of the membrane; and optionally repeating steps (a) and (b), and further comprising providing a sensor comprising a sensing region, wherein the sensor is suitable for detecting and/or quantifying the amount of analyte in a sample;
forming the ROS-quenching analyte-permeable membrane into a barrier layer on at least a part of the sensing region and wherein the sensor is adapted so that analyte enters the sensing region of the sensor through said barrier layer.- View Dependent Claims (14)
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15. A reactive oxygen species (ROS)-quenching, analyte-permeable membrane, suitable for use in an optical sensor for detecting and/or quantifying the amount of analyte in a sample, the membrane having an ROS-quenching activity sufficient to quench a solution of H2O2 having a concentration of 10 ppm, wherein said membrane is obtainable by a process comprising:
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(a) contacting a polypropylene hollow fibre membrane with a ROS-quenching precursor and a reducing agent; (b) reducing the ROS-quenching precursor within pores of the polypropylene hollow fibre membrane to form a ROS-quenching agent within the pores of the polypropylene hollow fibre membrane; and
optionally repeating steps (a) and (b). - View Dependent Claims (16, 17)
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18. A sensor for detecting and/or quantifying the amount of analyte in a sample, the sensor comprising:
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a sensing region; and a barrier layer comprising a reactive oxygen species (ROS)-quenching, analyte-permeable membrane having an ROS-quenching agent adsorbed thereto; wherein the sensor is adapted so that the sample enters the sensing region of the sensor through said barrier layer, wherein the ROS-quenching, analyte-permeable membrane is obtainable by a process comprising; (a) contacting a polypropylene hollow fibre membrane with a ROS-quenching precursor and a reducing agent; (b) reducing the ROS-quenching precursor within pores of the polypropylene hollow fibre membrane to form a ROS-quenching agent within the pores of the polypropylene hollow fibre membrane; and optionally repeating steps (a) and (b). - View Dependent Claims (19, 20)
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Specification