Charged particle cancer therapy dose distribution method and apparatus

• US 8,941,084 B2
• Filed: 05/05/2013
• Issued: 01/27/2015
• Est. Priority Date: 05/22/2008
• Status: Active Grant

• Current Assignee: Andrey Vladimirovich Balakin, Pavel Vladimirovich Balakin
• Original Assignee: Vladimir Balakin
• Inventors: Balakin, Vladimir
• Primary Examiner(s): IPPOLITO, NICOLE MARIE
• Application Number:
  US13/887,339
• Publication Number:
  US 20140330063A1
• Time in Patent Office: 632 Days
• Field of Search: 250/492.1, 250/492.3, 600/1, 315/500, 315/501, 315/502, 315/503, 315/504, 315/505, 315/506, 315/507
• US Class Current: 250/492.3
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 5/1049 for verifying the position of the patient with respect to the radiation beam
• CPC Class Codes: A61N 5/1067 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/107 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/1081 Rotating beam systems with a specific mechanical construction, e.g. gantries
• CPC Class Codes: H05H 13/04 Synchrotrons
• CPC Class Codes: H05H 7/10 Arrangements for ejecting particles from orbits

Abstract

The invention relates generally to treatment of solid cancers. More particularly, a method and apparatus for efficient radiation dose delivery to a tumor is described. Preferably, radiation is delivered through an entry point into the tumor and Bragg peak energy is targeted to a distal or far side of the tumor from an ingress point. Delivering Bragg peak energy to the distal side of the tumor from the ingress point is repeated from multiple rotational directions. Beam intensity is proportional to radiation dose delivery efficiency. The multi-field irradiation process with energy levels targeting the far side of the tumor from each irradiation direction provides even and efficient charged particle radiation dose delivery to the tumor. Preferably, the charged particle therapy is timed to patient respiration via control of charged particle beam injection, acceleration, extraction, and/or targeting methods and apparatus.

Claims

1. An apparatus for irradiating a tumor of a patient with charged particles, comprising:

a charged particle therapy system, comprising;

a synchrotron, said synchrotron comprising;

a radio-frequency cavity system configured to induce and amplify betatron oscillation of the charged particles;

an extraction foil, said extraction foil comprising a thickness of between ten and one hundred fifty micrometers, said extraction foil consisting essentially of atoms comprising six or fewer protons per atom, said extraction foil configured to emit electrons when struck by the charged particles undergoing betatron oscillation;

an intensity controller configured to;

(1) receive a signal related to the emitted electrons and (2) instruct said radio-frequency cavity system to enhance the betatron oscillation when a pathlength through healthy tissue to the tumor decreases and to decrease the betatron oscillation when the pathlength through the healthy tissue to the tumor increases;

a charged particle beam path; and

a rotatable platform,

wherein said charged particle beam path runs through said synchrotron and above a portion of said rotatable platform,

said rotatable platform configured to rotate at least ninety degrees during an irradiation period,

wherein, during use in said irradiation period, said rotatable platform rotates to at least five irradiation positions.

2. The apparatus of claim 1, said rotatable platform configured to hold the patient during said irradiation period, wherein the charged particle beam path circumferentially surrounds the charged particles, and wherein, during use, the charged particles irradiate the tumor during each of said at least five irradiation positions.

3. The apparatus of claim 1, wherein, during use, said rotatable platform rotates through about three hundred sixty degrees during said irradiation period.

4. The apparatus of claim 3, said charged particle therapy system further comprising:

an irradiation control module, wherein the tumor comprises a distal region, said distal region furthest from point of entry of the charged particles into the patient, said irradiation control module configured to terminate said charged particle beam path in said distal region of the tumor for each of said at least five irradiation positions.

5. The apparatus of claim 4, wherein said irradiation control module controls both rotation of said rotatable platform and energy of the charged particles to irradiate, with Bragg peak energy of the charged particles, a changing distal position of the tumor as a function of position of said rotatable platform.

6. The apparatus of claim 4, wherein said irradiation control module controls energy of the charged particles to maximize charged particle delivery efficiency of charged particle delivery of the tumor, wherein said charged particle delivery efficiency comprises a measure of charged particle energy delivered to the tumor relative to charged particle energy delivered to healthy tissue.

7. The apparatus of claim 1, said charged particle therapy system further comprising:

a control module, said control module configured to distribute distal energy of the charged particles about an outer perimeter of the tumor, wherein ingress energy of the charged particles comprises circumferential distribution about the tumor.

8. The apparatus of claim 1, further comprising a control algorithm, said control algorithm configured to control both energy and intensity of the charged particles during an extraction phase of the charged particles from said synchrotron.

9. The apparatus of claim 1, said charged particle therapy system configured to increase intensity of the charged particles when charged particle delivery efficiency increases and decrease said intensity when said charged particle delivery efficiency decreases, wherein said charged particle delivery efficiency comprises a measure of relative energy delivered to the tumor versus surrounding healthy tissue.

10. The apparatus of claim 9,

said extraction foil proximate said charged particle beam path in said synchrotron, wherein said thickness of said extraction foil comprises a width of forty to sixty micrometers.

11. The apparatus of claim 1, wherein a first intensity of the charged particles is used when energy levels of the charged particles reach a distal region of the tumor during each of said at least five irradiation positions, wherein a second intensity of the charged particles is used when energy levels of the charged particles reach an ingress region of the tumor during said each of said at least five irradiation positions, wherein said first intensity is greater than said second intensity.

12. The apparatus of claim 1, wherein intensity of the charged particles and energy of the charged particles correlate with a correlation factor of at least one-half.

13. The apparatus of claim 1, said charged particle therapy system further comprising:

a control module, said control module configured to increase intensity of the charged particles as energy of the charged particles increases for at least three of said at least five irradiation positions.

14. The apparatus of claim 1, wherein, during use, said rotatable platform rotates through about three hundred sixty degrees during said irradiation period, wherein irradiation of the tumor occurs with the charged particles in at least thirty rotation positions of said rotatable platform during said irradiation period.

15. The apparatus of claim 1, wherein said charged particle therapy system further comprises:

an active scanning system configured to scan the charged particles along at least three axes, said active scanning system comprising a focal spot of the charged particles of less than three millimeters diameter, wherein said three axes comprise;

a horizontal axis, a vertical axis, and an applied energy axis.

16. The apparatus of claim 15, wherein, during use, said rotatable platform rotates to a new position of said at least five irradiation positions between movement of said focal spot by said active scanning system.

17. A method for irradiating a tumor of a patient with charged particles, comprising the steps of:

providing a charged particle therapy system, comprising;

a synchrotron, said synchrotron comprising;

a radio-frequency cavity system configured to induce and amplify betatron oscillation of the charged particles,

an extraction foil, said extraction foil comprising a thickness of between ten and one hundred fifty micrometers, said extraction foil consisting essentially of atoms comprising six or fewer protons per atom;

said extraction foil emitting electrons when struck by the charged particles undergoing betatron oscillation;

receiving to an intensity controller a signal related to the emitted electrons;

instructing said radio-frequency cavity system to increase the betatron oscillation when a pathlength through healthy tissue to the tumor decreases and to decrease the betatron oscillation when the pathlength through the healthy tissue to the tumor increases;

rotating a rotatable platform at least ninety degrees during an irradiation period; and

rotating said rotatable platform to at least five irradiation positions during the irradiation period,

wherein a charged particle beam path runs through said synchrotron and above a portion of said rotatable platform.