Medical system comprising a percutaneous probe

• US 8,942,781 B2
• Filed: 04/09/2009
• Issued: 01/27/2015
• Est. Priority Date: 04/09/2008
• Status: Active Grant

• Current Assignee: Assistance Publique - Hopitaux De Paris, University Pierre et Marie Curie
• Original Assignee: Assistance Publique - Hopitaux De Paris, University Pierre et Marie Curie
• Inventors: Carpentier, Alexandre, Itzcovitz, Julian
• Primary Examiner(s): KISH, JAMES M
• Application Number:
  US12/937,166
• Publication Number:
  US 20110040172A1
• Time in Patent Office: 2,119 Days
• Field of Search: 600/407, 600/437, 600/473, 600/476, 600/410, 601/2, 601/3, 604/48, 604/93.01, 604/164.01
• US Class Current: 600/407
• CPC Class Codes: A61B 2017/00084 Temperature
• CPC Class Codes: A61B 2017/00911 for fields applied by a magnetic resonance imaging system
• CPC Class Codes: A61B 2090/374 NMR or MRI
• CPC Class Codes: A61B 2090/3784 both receiver and transmitter being in the instrument or receiver being also transmitter
• CPC Class Codes: A61B 5/0068 Confocal scanning
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/6848 Needles
• CPC Class Codes: A61B 8/0833 involving detecting or locating foreign bodies or organic structures
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61N 2007/0073 using multiple frequencies
• CPC Class Codes: A61N 2007/025 interstitial
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00

Abstract

The percutaneous probe, made in MRI-compatible materials, comprises: a body percutaneously inserted into the tissue of a patient'"'"'s body organ (8) having a region (10) to be analyzed, treated and monitored during a single medical procedure; at least one information collection sensing device (30,33,34); treatment application transducers (30) 360° disposed to emit focused or defocused therapeutic ultra-sound waves. The computerized system comprises a parametrizable command device (50) adapted to simulate then command a generation of the therapeutic ultra-sound waves, and to monitor the treatment by thermal MRI images.

Claims

1. A percutaneous probe of MRI-compatible materials, the percutaneous probe comprising:

a body made of MRI-compatible materials and having an insertion end shaped to be percutaneously inserted into tissue of a patient'"'"'s body organ having a region to be analyzed, treated and monitored during a single medical procedure, the body of the percutaneous probe including a cavity, the cavity being configured to insert fluid into the patient through an opening in the insertion end of the body, to collect a part of said tissue from the patient'"'"'s body through the opening, and to decrease in volume said region of the organ after treatment by allowing substances to be aspirated through the opening into the cavity,

a rigid mandrel shaped to be inserted into the cavity,

at least one information collection sensing device, adapted to collect information about the region of the organ, and

a plurality of treatment application transducers disposed all around a circumference and a length of a part of the body of the probe which is to be inserted in the region to be treated, the plurality of treatment application transducers being operable as a phased-array, adapted to emit both focused and not-focused therapeutic ultra-sound waves to the region of the organ.

2. The percutaneous probe according to claim 1, wherein the information collection sensing device comprises at least one ultra-sound transducer adapted to perform ultra-sound imaging of the body organ, and

wherein each transducer is adapted to be operated in an imaging mode, wherein it operates as the information collection sensing device, and in a therapeutic mode, wherein it operates as the treatment application transducer.

3. The percutaneous probe according to claim 1, comprising an aspiration device adapted to collect the part of said tissue from the patient'"'"'s body through the cavity of the probe body.

4. The percutaneous probe according to claim 1, wherein the information collection sensing device comprises at least one of the following:

at least one electro-encephalography electrode adapted to collect brain physiological signals,

at least one biosensor adapted to collect tissue physiological signals,

at least one thermal electrode adapted to measure the temperature of the region,

a biopsy needle adapted to collect tissue.

5. The percutaneous probe according to claim 1, comprising fluid evacuation circuitry, adapted to evacuate fluid from the organ through the probe body.

6. The percutaneous probe according to claim 1 comprising fluid circuitry adapted to allow a cooling fluid to flow in the probe body.

7. The percutaneous probe according to claim 1 wherein treatment application transducers are adapted to generate a temperature rise of at least 30°

C., within less than 1 s, in a treatment region of spherical shape of at least 2 mm in diameter neighbouring the treatment application device.

8. The percutaneous probe according to claim 1 wherein the treatment application transducers are adapted to generate a temperature rise of at least 30°

C., within less than 10 nm, within a envelope of 30 mm of cross-sectional diameter around the probe.

9. The percutaneous probe of claim 1, further comprising an optical head of an endo-confocal microscope.

10. The percutaneous probe according to claim 1, wherein the transducers are arranged in a convex manner on the body of the percutaneous probe.

11. A medical system comprising:

a percutaneous probe of MRI-compatible materials, the percutaneous probe including;

a body made of MRI-compatible materials and having an insertion end shaped to be percutaneously inserted into tissue of a patient'"'"'s body organ having a region to be analyzed, treated and monitored during a single medical procedure, the body of the percutaneous probe comprising a cavity, the cavity being configured to insert fluid into the patient through an opening in the insertion end of the body, to collect a part of said tissue from the patient'"'"'s body through the opening, and to decrease in volume said region of the organ after treatment by allowing substances to be aspirated through the opening into the cavity,

a rigid mandrel shaped to be inserted into the cavity,

at least one information collection sensing device, adapted to collect information about the region of the organ, and

a plurality of treatment application transducers disposed all around a circumference and a length of a part of the body of the probe which is to be inserted in the region to be treated, the plurality of treatment application transducers being operable as a phased-array, adapted to emit both focused and not-focused therapeutic ultra-sound waves to the region of the organ; and

a computerized system comprising a parametrizable command device and associated equipment adapted to command a generation of the therapeutic ultra-sound wave.

12. The medical system according to claim 11, wherein the computerized system comprises an imaging device adapted to generate an image from sensed ultra-sound.

13. The medical system according to claim 11 wherein the percutaneous probe comprises fluid circuitry adapted to allow a cooling fluid to flow in the probe body, and wherein the computerized system comprises a pulsed pump command adapted to generate a flow of the cooling fluid in the probe body.

14. The medical system according to claim 11, wherein the percutaneous probe comprises an aspiration device adapted to collect the part of said tissue from the patient'"'"'s body through the cavity of the probe'"'"'s body, wherein the computerized system comprises a continuous pump command adapted to aspirate through the probe body.

15. The medical system according to claim 11, wherein the computerized system comprises at least one power amplifier adapted to generate and transfer to the treatment application transducers a power sufficient for emission of the therapeutic ultra-sound waves to the region of the body organ.

16. The medical system according to claim 11, wherein the computerized system comprises a setting device adapted to set parameters of the therapeutic ultra-sound waves.

17. The medical system according to claim 11, wherein the computerized system comprises an MRI interface adapted to be connected to an MRI system and to receive MRI data of the patient'"'"'s body therefrom, and software adapted to generate and manipulate MRI images.

18. The medical system according to claim 11 wherein the computerized system further comprises software adapted to generate and manipulate at least ultra-sound and confocal microscopy images.

19. The medical system according to claim 11, wherein the computerized system includes a simulation software adapted to determine parameters of the therapeutic ultra-sound waves.

20. The medical system according to claim 19, wherein the simulation software is adapted to model the probe and the geometry of region of the organ to be analyzed, treated and monitored to estimate said parameters.

21. A medical system according to claim 11, wherein the percutaneous probe comprises fluid circuitry adapted to allow a cooling fluid to flow in the probe body, wherein the computerized system comprises a continuous pump command adapted to aspirate through the probe body.

22. The medical system according to claim 11, wherein the transducers are arranged in a convex manner on the body of the percutaneous probe.

23. A method of analyzing, treating and monitoring a region of a body organ having a region to be analyzed, treated and monitored during a single medical procedure, the method comprising:

inserting an insertion end of a percutaneous probe into tissue of the body organ by using a rigid mandrel shaped inserted into a cavity of the body of the percutaneous probe, wherein the percutaneous probe is made from MRI compliant materials and comprises a body,

removing the rigid mandrel while simultaneously bringing fluid through the cavity after inserting the insertion end of the percutaneous probe into tissue of the body organ

collecting information about the region of the organ with an information collection sensing device of the probe by performing a biopsy through the cavity,

setting parameters of at least one of a focused and not-focused therapeutic ultra-sound waves to be emitted to the region of the organ with a plurality of treatment application transducers of the probe disposed all around a circumference and a length of a part of the body of the probe which is to be inserted in the region to be treated, the plurality of treatment application transducers being configured as a phase-array through a parametrizable command device and associated equipment of a computerized system,

after treatment, decreasing in volume said region of the organ by aspiring substances from the patient'"'"'s body through the cavity.

24. The method according to claim 23 further comprising performing an analysis of the collected information and setting parameters of the therapeutic ultra-sound waves based on said analysis.

25. The method according to claim 23 further comprising emitting said therapeutic ultra-sound waves.

26. The method according to claim 25 further comprising monitoring an efficiency of the therapy ultra-sound waves.

27. The method according to claim 23 further comprising performing the biopsy by aspiring through the cavity a part of the body organ.

28. The method according to claim 23, further comprising collecting information about the region of the organ with an information collection sensing device of the probe, and with an optical head of an endo-confocal microscope.

29. The method according to claim 23, wherein the transducers are arranged in a convex manner on the body of the percutaneous probe.