Systems and devices for generating nitric oxide

• US 8,944,049 B2
• Filed: 12/16/2013
• Issued: 02/03/2015
• Est. Priority Date: 08/21/2008
• Status: Active Grant

• Current Assignee: Vero Biotech LLC
• Original Assignee: GENO LLC
• Inventors: Fine, David H., Johnson, Bryan, Vasquez, Gregory
• Primary Examiner(s): Yu, Justine
• Assistant Examiner(s): Stuart, Colin W
• Application Number:
  US14/107,554
• Publication Number:
  US 20140102447A1
• Time in Patent Office: 414 Days
• Field of Search: 128/202.26, 128/200.24, 128/203.12, 128/203.22, 128/204.14, 128/204.18, 422/129, 423/402
• US Class Current: 128/202.26
• CPC Class Codes: A61M 16/10 Preparation of respiratory gases or vapours
• CPC Class Codes: A61M 16/104 specially adapted for anaesthetics A61M16/18 takes precedence
• CPC Class Codes: A61M 16/107 in the inspiratory path
• CPC Class Codes: A61M 16/1075 by influencing the temperature A61M16/1045 takes precedence
• CPC Class Codes: A61M 16/109 the humidifying liquid or the beneficial agent
• CPC Class Codes: A61M 16/12 by mixing different gases
• CPC Class Codes: A61M 16/16 Devices to humidify the respiration air A61M16/1045 takes precedence
• CPC Class Codes: A61M 2202/0275 Nitric oxide [NO]
• CPC Class Codes: A62B 21/00 Devices for producing oxygen from chemical substances for respiratory apparatus
• CPC Class Codes: A62B 7/08 containing chemicals producing oxygen
• CPC Class Codes: C01B 21/24 Nitric oxide (NO) C01B21/203 takes precedence

Abstract

Various systems and devices for generating nitric oxide are disclosed herein. According to one embodiment, the device includes a body having an inlet, an outlet, and a porous solid matrix positioned with the body. The porous solid matrix is coated with an aqueous solution of an antioxidant, wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the solid matrix to convert nitrogen dioxide in the gas flow into nitric oxide. The porous solid matrix allows the device to be used in any orientation. Additionally, the porous solid matrix provides a rigid structure suitable to withstand vibrations and abuse without compromising device functionality.

Claims

1. A device for generating nitric oxide from nitrogen dioxide, comprising:

a receptacle including an inlet, an outlet and a diverter,

a porous solid matrix including an antioxidant positioned within the receptacle, and

a space between the receptacle and the porous solid matrix,

wherein the space has a width, which is the distance between an outer surface of the porous solid matrix to the receptacle, and the width of the space is variable along a length of the receptacle, and

wherein the inlet is configured to receive a gas flow, the diverter directs the gas flow to the space between the receptacle and the porous solid matrix, and the gas flow is fluidly communicated to the outlet through the porous solid matrix to convert nitrogen dioxide in the gas flow into nitric oxide.

2. The device of claim 1, wherein the width of the space decreases along a portion of the length of the receptacle.

3. The device of claim 1, wherein the width of the space increases along a portion of the length of the receptacle.

4. The device of claim 1, wherein the width of the space increases along a portion of the length of the receptacle extending from the inlet to approximately the midpoint of the receptacle, and the width of the space decreases along a portion of the length of the receptacle extending from approximately the midpoint of the receptacle to the outlet.

5. A system for delivering nitric oxide to a patient, comprising:

a gas source of nitrogen dioxide, dinitrogen tetraoxide, or nitric oxide;

a first device having a receptacle including an inlet, an outlet and a diverter, a porous solid matrix including an antioxidant positioned within the receptacle, and a space between the receptacle and the porous solid matrix, wherein the space has a width, which is the distance between an outer surface of the porous solid matrix to the receptacle, and the width of the space is variable along a length of the receptacle, and wherein the inlet is configured to receive a gas flow, the diverter directs the gas flow to the space between the receptacle and the porous solid matrix, and the gas flow is fluidly communicated to the outlet through the porous solid matrix to convert nitrogen dioxide in the gas flow into nitric oxide; and

a patient interface coupled to the outlet of the first device, the patient interface delivering nitric oxide to the patient.

6. The system of claim 5, further comprising a humidifier positioned between the gas source and the first device.

7. The system of claim 6, wherein the humidifier is integral with the first device.

8. The system of claim 5, further comprising a humidifier positioned prior to the patient interface.

9. The system of claim 6, wherein the humidifier has a temperature between 18°

C. and 23°

C.

10. The system of claim 8, wherein the humidifier has a temperature of between 32°

C. and 37°

C.

11. The system of claim 6, further comprising:

a second humidifier positioned after the first device; and

a second device positioned after a second humidifier, the second device having a receptacle including an inlet, an outlet and a diverter, a porous solid matrix including an antioxidant positioned within the receptacle, and a space between the receptacle and the porous solid matrix, wherein the space has a width, which is the distance between an outer surface of the porous solid matrix to the receptacle, and the width of the space is variable along a length of the receptacle, and wherein the inlet is configured to receive a gas flow, the diverter directs the gas flow to the space between the receptacle and the porous solid matrix, and the gas flow is fluidly communicated to the outlet through the porous solid matrix to convert nitrogen dioxide in the gas flow into nitric oxide.