Method and device for calculating a bolus amount

• US 8,945,085 B2
• Filed: 09/07/2006
• Issued: 02/03/2015
• Est. Priority Date: 03/08/2004
• Status: Active Grant

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diagnostics International AG (Roche Holding AG)
• Inventors: Hellwig, Robert
• Primary Examiner(s): MENDEZ, MANUEL A
• Application Number:
  US11/470,841
• Publication Number:
  US 20070282299A1
• Time in Patent Office: 3,071 Days
• Field of Search: 604500-505, 604 65- 67, 604/131, 604/151, 128/DIG.12, 128/DIG.13
• US Class Current: 604/504
• CPC Class Codes: A61M 2005/14208 with a programmable infusion control system, characterised by the infusion program
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61P 5/48 of the pancreatic hormones
• CPC Class Codes: G16H 20/17 delivered via infusion or injection

Abstract

A method for calculating a bolus amount, wherein the bolus amount is calculated according to a basal rate, and a device for calculating a bolus amount according to the method, the device including an input unit used to input an amount of received carbohydrates, a computer coupled to the input unit and at least one interface used to transmit an actual blood glucose value and the value of the actual basal rate to the computer, wherein the at least one interface or another interface transmits a bolus amount calculated by the computer.

Claims

1. A method for calculating a bolus amount for a patient on the basis of a constantly changing basal rate, a time course of the constantly changing basal rate being stored in a memory connected to a microprocessor, the method comprising:

providing to the microprocessor an amount of carbohydrate to be consumed;

providing to the microprocessor a blood glucose level measured on a blood glucose measuring device;

providing to the microprocessor a nominal blood glucose value;

providing to the microprocessor information about a current time of day;

calculating with the microprocessor a value for an amount of insulin needed to process one gram of carbohydrate at the current time (A′

_meal), said calculating being based on a factor correlating A′

_meal and a value of the constantly changing basal rate for the current time of day (BR_actual); and

calculating with the microprocessor the bolus amount using the amount of carbohydrate to be consumed, the blood glucose level, the nominal blood glucose value, and A′

_meal.

2. The method as claimed in claim 1, wherein BR_actual is ascertained from a preset amount of a daily insulin requirement.

3. The method as claimed in claim 1, further comprising calculating with the microprocessor a value for reduction of a blood-glucose value by one unit of insulin at the current time (D′

_correction) using BR_actual, and wherein calculating the bolus amount further comprises using D′

_correction.

4. The method of claim 3 wherein D′

_correction is calculated using the following formula;

D′

_correction[mmol*I<sup>−

1</sup>*I.U.<sup>−

1</sup>]=CF_D[mmol*I<sup>−

1</sup>*h*I.U.<sup>−

2</sup>]*BR_actual[I.U.*h<sup>−

1</sup>]

where CF_D is a constant.

5. The method of claim 4 wherein CF_D is calculated using the following formula:

6. The method as claimed in claim 1, wherein at least one preset parameter is used to calculate the bolus amount.

7. The method as claimed in claim 6, wherein the nominal blood-glucose value is the preset parameter.

8. The method as claimed in claim 1, further comprising calculating with the microprocessor an amount of insulin that has already been infused, and wherein calculating the bolus amount further comprises using the amount of insulin that has already been infused.

9. The method of claim 1 wherein the factor which correlates A′

_meal and BR_actual is calculated using the following formula;

CF_A[h*g<sup>−

1</sup>]*BR_actual[I.U.*h<sup>−

1</sup>]

where CF_A is the factor which applies at the current time.

10. The method of claim 9, further comprising calculating with the microprocessor the factor CF_A using the following formula:

11. The method of claim 1 wherein the amount of carbohydrate to be consumed is provided by inputting on an input device.

12. The method of claim 1 further comprising transmitting the bolus amount to an infusion pump, and administering the bolus amount.

13. The method of claim 12 wherein the bolus amount is transmitted to the infusion pump using an interface or a wireless transmitter and further comprising displaying the bolus amount on an output device.

14. The method of claim 1 further comprising storing the nominal blood glucose value in the memory.

15. A method for calculating a bolus amount on the basis of a constantly changing basal rate, a time course of the constantly changing basal rate being stored in a memory connected to a microprocessor, the method comprising

providing to the microprocessor an amount of carbohydrate to be consumed;

providing to the microprocessor a blood glucose level measured on a blood glucose measuring device;

providing to the microprocessor a nominal blood glucose value;

providing to the microprocessor information about a current time of day;

calculating with a microprocessor a value for an amount of insulin needed to process one gram of carbohydrate at the current time (A′

_meal), said calculating being based on a factor correlating A′

_meal and a value of the constantly changing basal rate for the current time of day (BR_actual);

calculating with the microprocessor a value for the reduction of a blood-glucose value by one unit of insulin at the current time (D′

_correction) using BR_actual ; and

calculating with the microprocessor the bolus amount using the amount of carbohydrate to be consumed, the blood glucose level, the nominal blood glucose value, A′

_meal and D′

_correction.

16. The method as claimed in claim 15, further comprising ascertaining with the microprocessor BR_actual from a preset amount of a daily insulin requirement.

17. The method as claimed in claim 15, further comprising calculating with the microprocessor the bolus amount using at least one preset parameter, wherein the nominal blood-glucose value is the preset parameter.

18. The method as claimed in claim 15, further comprising calculating with the microprocessor an amount of insulin that has already been infused, and wherein calculating the bolus amount further comprises the amount of insulin that has already been infused.

19. The method of claim 15 further comprising transmitting the bolus amount to an infusion pump, and administering the bolus amount.

20. The method of claim 15 further comprising storing the nominal blood glucose value in the memory.

21. The method of claim 15 wherein the factor which correlates A′

_meal and BR_actual is calculated using the following formula;

CF_A[h*g<sup>−

1</sup>]*BR_actual[I.U.*h<sup>−

1</sup>]

where CF_A is the factor which applies at the current time.

22. The method of claim 21 wherein D′

_correction is calculated using the following formula;

D′

_correction[mmol*I<sup>−

1</sup>*I.U.<sup>−

1</sup>]=CF_D[mmol*I<sup>−

1</sup>*h*I.U.<sup>−

2</sup>]*BR_actual[I.U.*h<sup>−

1</sup>]

where CF_D is a constant.