Devices for restoring blood flow and clot removal during acute ischemic stroke

• US 8,945,172 B2
• Filed: 12/30/2011
• Issued: 02/03/2015
• Est. Priority Date: 10/17/2007
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Covidien LP (Medtronic Plc)
• Inventors: Ferrera, David A., Cragg, Andrew H., Fulkerson, John
• Primary Examiner(s): NGUYEN, TUAN VAN
• Application Number:
  US13/341,186
• Publication Number:
  US 20120116443A1
• Time in Patent Office: 1,131 Days
• Field of Search: 606/1, 606/108, 606/113, 606/127, 606/128, 606/191, 606/192, 606/193, 606/194, 606/198, 606/200, 623/1.15
• US Class Current: 606/200
• CPC Class Codes: A61B 17/221 Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions surgical snare instruments A61B17/32056
• CPC Class Codes: A61B 17/320783 through side-hole, e.g. sliding or rotating cutter inside catheter
• CPC Class Codes: A61B 2017/22039 eccentric
• CPC Class Codes: A61B 2017/22094 for crossing total occlusions, i.e. piercing
• CPC Class Codes: A61B 2017/2212 having a closed distal end, e.g. a loop
• CPC Class Codes: A61F 2/013 Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting
• CPC Class Codes: A61F 2002/016 made from wire-like elements
• CPC Class Codes: A61F 2230/0069 cylindrical
• CPC Class Codes: A61F 2230/0076 ellipsoidal or ovoid
• CPC Class Codes: A61F 2230/0097 Harpoon-shaped
• CPC Class Codes: A61M 25/09 Guide wires
• CPC Class Codes: A61M 25/09025 with sliding mandrils

Abstract

Devices for restoring blood flow to facilitate lysis of clots and/or enable capture of clots are disclosed. The devices can be configured to be disposed within a lumen of a microcatheter that is inserted within neurovasculature above a carotid siphon to a location of a clot. The devices can include an elongate pusher member and a self-expandable capturing member coupled to a distal end of the elongate pusher member. The capturing member can comprise a generally cylindrical body having an cell structure that is configured to compress the clot against an inner wall of the neurovasculature and capture the clot at least partially on a surface of the generally cylindrical body upon deployment of the capturing member from the microcatheter, thereby restoring blood flow to the neurovasculature downstream of the clot.

Claims

1. A catheter-based blood-flow restoration system configured to restore blood flow in an occluded blood vessel of a subject'"'"'s neurovasculature, comprising:

a microcatheter having a lumen,

a blood flow restoration device configured to be disposed within the lumen of the microcatheter,

wherein the blood flow restoration device comprises a self-expandable capturing member coupled to a distal end of an elongate delivery member, the elongate delivery member comprising a tubular member, a coil, and a shrink tube, the tubular member joined to the coil at a joint, the shrink tube surrounding the joint and extending proximally and distally of the joint,

wherein the self-expandable capturing member is configured to be delivered through the microcatheter in a compressed configuration and deployed to an expanded configuration upon retraction of the microcatheter at a location of a clot,

wherein the capturing member comprises a generally cylindrical body having an open-cell structure that is configured to compress the clot against an inner wall of the neurovasculature upon deployment of the capturing member from the microcatheter, thereby restoring blood flow through the neurovasculature downstream of the clot,

wherein the generally cylindrical body comprises a mouth at a side of the body, the mouth being configured to accept passage of the clot to within the capturing device, the mouth being larger than any cell of the open-cell structure, and an entire perimeter of the mouth being positioned at a radially outermost periphery of the body,

wherein a proximal end of the generally cylindrical body is closed and tapered in the expanded configuration; and

wherein a distal end of the generally cylindrical body is closed in the expanded configuration.

2. The blood flow restoration system of claim 1, wherein the generally cylindrical body comprises a woven mesh.

3. The blood flow restoration system of claim 1, wherein the mouth is positioned at approximately a mid-section of the generally cylindrical body.

4. The blood flow restoration system of claim 1, wherein the clot is located within a cerebral artery of the neurovasculature above the carotid siphon.

5. The blood flow restoration system of claim 1, wherein the generally cylindrical body is configured to exert a sufficient force on the clot to hold the clot against the inner wall of the neurovasculature such that the clot is not displaced while blood flow is restored.

6. The blood flow restoration system of claim 1, wherein the open-cell structure allows passage of at least a portion of the clot from the exterior of the cylindrical body to the interior of the cylindrical body.

7. The blood flow restoration system of claim 1, wherein the capturing member is coupled to the elongate delivery member by a plurality of tether lines.

8. The blood flow restoration system of claim 7, wherein the capturing member is tethered off-center to the elongate delivery member.

9. The blood flow restoration system of claim 1, wherein a distal end of the self-expandable capturing member forms a distal end of the blood flow restoration system when the self-expandable capturing member is deployed to the expanded configuration.

10. A blood flow restoration device configured to be disposed within a lumen of a microcatheter, comprising:

an elongate pusher member comprising a tubular member, a coil, and a shrink tube, the tubular member joined to the coil at a joint, the shrink tube surrounding the joint and extending proximally and distally of the joint; and

a self-expandable capturing member coupled to a distal end of the elongate pusher member,

wherein the self-expandable capturing member is configured to be delivered through a microcatheter in a compressed configuration and deployed to an expanded configuration upon retraction of the microcatheter at the location of a clot within a vessel,

wherein the capturing member comprises a generally cylindrical body having an open-cell structure that is configured to compress the clot against an inner wall of the vessel upon deployment of the capturing member from the microcatheter, thereby restoring blood flow through the vessel downstream of the clot,

wherein the generally cylindrical body comprises a mouth at a side of the body, the mouth being configured to accept passage of the clot to within the capturing device, the mouth being larger than any cell of the open-cell structure, and an entire perimeter of the mouth being positioned at a radially outermost periphery of the body, and

wherein both a proximal end and a distal end of the generally cylindrical body are closed in the expanded configuration.

11. The blood flow restoration device of claim 10, wherein the generally cylindrical body comprises a woven mesh.

12. The blood flow restoration device of claim 10, wherein the generally cylindrical body is configured to exert a sufficient force on the clot to hold the clot against the inner wall of the vessel such that the clot is not displaced while blood flow is restored.

13. The blood flow restoration device of claim 10, wherein the open-cell structure allows passage of at least a portion of the clot from the exterior of the generally cylindrical body to the interior of the generally cylindrical body.

14. The blood flow restoration device of claim 10, wherein the capturing member is tethered off-center to the elongate pusher member by a plurality of tether lines.

15. The blood flow restoration device of claim 10, wherein the proximal end of the generally cylindrical body is tapered in the expanded configuration.

16. The blood flow restoration device of claim 10, wherein a distal end of the self-expandable capturing member forms a distal end of the blood flow restoration device when the self-expandable capturing member is deployed to the expanded configuration.

17. A blood flow restoration device configured to be disposed within a lumen of a microcatheter, comprising:

an elongate pusher member comprising a tubular member, a coil, and a shrink tube, the tubular member joined to the coil at a joint, the shrink tube surrounding the joint and extending proximally and distally of the joint; and

a self-expandable capturing member coupled to a distal end of the elongate pusher member,

wherein the self-expandable capturing member is configured to be delivered through a microcatheter in a compressed configuration and deployed to an expanded configuration upon retraction of the microcatheter at the location of a clot within a blood vessel of a subject'"'"'s neurovasculature,

wherein the capturing member comprises a generally cylindrical body having an open-cell structure that is configured to compress the clot against an inner wall of the blood vessel upon deployment of the capturing member from the microcatheter, thereby restoring blood flow through the blood vessel downstream of the clot,

wherein the generally cylindrical body comprises a mouth at a side of the body, the mouth being configured to accept passage of the clot to within the capturing device, the mouth being larger than any cell of the open-cell structure, and an entire perimeter of the mouth being positioned at a radially outermost periphery of the body,

wherein a proximal end of the generally cylindrical body is closed and tapered in the expanded configuration,

wherein a distal end of the generally cylindrical body is closed in the expanded configuration, and

wherein the capturing member is tethered off-center to the elongate pusher member by a plurality of tether lines.

18. The blood flow restoration device of claim 17, wherein the generally cylindrical body is configured to exert a sufficient force on the clot to hold the clot against the inner wall of the blood vessel such that the clot is not displaced while blood flow is restored.

19. The blood flow restoration device of claim 17, wherein a distal end of the self-expandable capturing member forms a distal end of the blood flow restoration device when the self-expandable capturing member is deployed to the expanded configuration.