Prosthesis delivery system

• US 8,945,201 B2
• Filed: 01/30/2013
• Issued: 02/03/2015
• Est. Priority Date: 01/30/2013
• Status: Expired due to Fees

• Current Assignee: Telesis Research LLC
• Original Assignee: Telesis Research LLC
• Inventors: Shokoohi, Mehrdad M.
• Primary Examiner(s): MILES, JONATHAN WADE
• Application Number:
  US13/754,811
• Publication Number:
  US 20140214148A1
• Time in Patent Office: 734 Days
• Field of Search: 623/1.11, 623/1.12, 623/1.23, 606/108, 606/200
• US Class Current: 623/1.12
• CPC Class Codes: A61F 2/95 Instruments specially adapted for placement or removal of stents or stent-grafts

Abstract

Disclosed herein are implantable, radially expandable medical prostheses, including but not limited to stents, and delivery and loading systems applicable to the same, including disposable, detachable distal chambers, and methods for using the same.

Claims

1. A prosthesis delivery system, comprising:

an elongate tubular body having a proximal end, tubular body, distal end, and a central lumen therethrough, the distal end comprising a distal chamber detachable from the remainder of the elongate tubular body, the distal chamber having a first rigid distal segment and a second flexible proximal transition segment, the first distal segment having an inner diameter, the inner diameter of the first distal segment being substantially constant and configured to house therethrough a prosthesis in a less than fully compressed configuration, the second proximal transition segment having an inner diameter that generally decreases from the distal end to the proximal end of the transition segment, the second proximal transition segment having an axial length that is at least 1.5×

the inner diameter of the first distal segment, the tubular body having an inner diameter smaller than the inner diameter of the first distal segment of the chamber, and

a retrieval element configured to move the prosthesis proximally from the chamber, through the transition segment into the tubular body, thereby transforming the prosthesis from the less than fully compressed configuration when stored in the chamber to a fully compressed configuration.

2. The prosthesis delivery system of claim 1, wherein the second proximal transition segment has an axial length that is at least 2×

the inner diameter of the first distal segment.

3. The prosthesis delivery system of claim 1, wherein the second proximal transition segment has an axial length that is at least 3×

the inner diameter of the first distal segment.

4. The prosthesis delivery system of claim 1, wherein the inner diameter of the second proximal transition segment gradually decreases from its distal end to its proximal end.

5. The prosthesis delivery system of claim 1, wherein at least a portion of a sidewall defining the inner diameter of the first distal segment of the distal chamber comprises a corona surface treatment.

6. The prosthesis delivery system of claim 1, wherein at least a portion of a sidewall defining the inner diameter of the first distal segment of the distal chamber comprises a hydrophilic surface treatment.

7. The prosthesis delivery system of claim 1, wherein the distal chamber comprises an element selected from the group consisting of:

a radioactive element, a drug, a stem cell, and a bioactive agent.

8. The prosthesis delivery system of claim 1, wherein the retrieval element comprises a control wire.

9. The prosthesis delivery system of claim 8, wherein the control wire comprises a suture.

10. The prosthesis delivery system of claim 1, wherein the retrieval element comprises a clamp.

11. The prosthesis delivery system of claim 1, wherein the retrieval element is configured to removably attach to the prosthesis.

12. The prosthesis delivery system of claim 1, wherein the retrieval element comprises a vacuum source operably connected to a proximal port on the tubular body.

13. The prosthesis delivery system of claim 1, wherein the retrieval element comprises a pressure source.

14. The prosthesis delivery system of claim 1, wherein the retrieval element comprises a control wire.

15. The prosthesis delivery system of claim 1, wherein the retrieval element is detachable from the tubular body via a friction fit.

16. The prosthesis delivery system of claim 1, wherein the retrieval element is detachable from the tubular body via a compression fit.

17. The prosthesis delivery system of claim 1, further comprising an expandable balloon proximate the distal end of the tubular body configured to radially expand the prosthesis.

18. The prosthesis delivery system of claim 17, further comprising a plurality of radiopaque marker elements positioned on the proximal end and a distal end of the balloon.

19. The prosthesis delivery system of claim 1, wherein at least a portion of the distal chamber has a see-through portion configured to allow an operator to visually gauge the relative position of the prosthesis within the delivery system.

20. The prosthesis delivery system of claim 1, wherein the tubular body comprises at least one fluid delivery port near the proximal end of the tubular body.

21. The prosthesis delivery system of claim 1, further comprising a guidewire configured to reside within the central lumen of the elongate tubular body.

22. The prosthesis delivery system of claim 1, wherein the chamber is disposable.

23. The prosthesis delivery system of claim 1, wherein the chamber comprises a first flange removably attached to a second flange of the tubular body, wherein the first flange and the second flange are angled with respect to a long axis of the chamber and a long axis of the tubular body.

24. The prosthesis delivery system of claim 23, wherein an inner surface of the first flange contacts an outer surface of the second flange.

25. The prosthesis delivery system of claim 23, wherein an outer surface of the first flange contacts an inner surface of the second flange.

26. A medical system comprising the prosthesis delivery system of claim 1, and an expandable prosthesis.

27. A method of delivering an expandable prosthesis, comprising:

providing a prosthesis delivery system having a detachable, disposable distal chamber removably attached at its proximal end to the distal end of a tubular body, the distal chamber having a first rigid distal segment and a second flexible proximal transition segment, the first distal segment having an inner diameter, the inner diameter of the first distal segment being substantially constant and configured to house therethrough the expandable prosthesis in a less than fully compressed configuration, the second proximal transition segment having an inner diameter that generally decreases from the distal end to the proximal end of the transition segment;

wherein the expandable prosthesis is stored in a first, relatively expanded state within the chamber; and

transferring the expandable prosthesis from the chamber to the tubular body by using vacuum or pressure to move the expandable prosthesis proximally, transforming the prosthesis from the first relatively expanded state to a second relatively compressed state during the transfer.

28. A method of delivering an expandable prosthesis, comprising:

providing a prosthesis delivery system having a detachable, disposable distal chamber removably attached at its proximal end to the distal end of a tubular body, the chamber having a proximal flexible transition segment and a distal rigid segment having a substantially constant outer diameter, the transition segment having a proximal end and a distal end, the transition segment having an axial length, a first inner diameter at the proximal end and a second inner diameter at the distal end, the transition segment having a first inner diameter that is less than the second inner diameter of the transition segment, the transition segment having an axial length that is at least about 2×

the outer diameter of the distal segment,

wherein the expandable prosthesis is stored in a first, relatively expanded state within the chamber; and

transferring the expandable prosthesis from the chamber to the tubular body to move the expandable prosthesis proximally, transforming the prosthesis from the first relatively expanded state to a second relatively compressed state during the transfer.

29. The method of claim 28, wherein transferring the prosthesis from the chamber to the tubular body comprises using vacuum.

30. The method of claim 28, wherein transferring the prosthesis from the chamber to the tubular body comprises using pressure.

31. The method of claim 28, wherein transferring the prosthesis from the chamber to the tubular body comprises moving a control wire removably connected to the prosthesis in a proximal direction.

32. The method of claim 28, further comprising delivering the prosthesis to a stenosis within a lumen of the body, and expanding the prosthesis to dilate the stenosis.