Bispecific, bivalent anti-VEGF/anti-ANG-2 antibodies
First Claim
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1. A purified bispecific, bivalent antibody comprising a first antigen-binding site that specifically binds to human VEGF and a second antigen-binding site that specifically binds to human ANG-2, wherein the antibody comprises the amino acid sequences of SEQ ID NO:
- 5, SEQ ID NO;
6, SEQ ID NO;
7, and SEQ ID NO;
8.
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Abstract
The present invention relates to bispecific, bivalent antibodies against human vascular endothelial growth factor (VEGF/VEGF-A) and against human angiopoietin-2 (ANG-2), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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Citations
12 Claims
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1. A purified bispecific, bivalent antibody comprising a first antigen-binding site that specifically binds to human VEGF and a second antigen-binding site that specifically binds to human ANG-2, wherein the antibody comprises the amino acid sequences of SEQ ID NO:
- 5, SEQ ID NO;
6, SEQ ID NO;
7, and SEQ ID NO;
8. - View Dependent Claims (2, 3, 4)
- 5, SEQ ID NO;
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5. A purified bispecific, bivalent antibody comprising a first antigen-binding site that specifically binds to human VEGF and a second antigen-binding site that specifically binds to human ANG-2, wherein the antibody comprises the amino acid sequences of SEQ ID NO:
- 9, SEQ ID NO;
10, SEQ ID NO;
11, and SEQ ID NO;
12. - View Dependent Claims (6, 7, 8)
- 9, SEQ ID NO;
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9. A purified bispecific, bivalent antibody comprising a first antigen-binding site that specifically binds to human VEGF and a second antigen-binding site that specifically binds to human ANG-2, wherein the antibody comprises the amino acid sequences of SEQ ID NO:
- 13, SEQ ID NO;
14, SEQ ID NO;
15, and SEQ ID NO;
16. - View Dependent Claims (10, 11, 12)
- 13, SEQ ID NO;
Specification