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RAF gene fusions

  • US 8,945,556 B2
  • Filed: 11/18/2011
  • Issued: 02/03/2015
  • Est. Priority Date: 11/19/2010
  • Status: Active Grant
First Claim
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1. A composition comprising at least one of the following:

  • (a) an oligonucleotide probe that hybridizes to a junction of a chimeric genomic DNA or a chimeric mRNA, wherein a 5′

    portion of the chimeric genomic DNA or the chimeric mRNA is from an AGTRAP gene and a 3′

    portion of the chimeric genomic DNA or the chimeric mRNA is from a RAF family member gene;

    (b) an antibody specific for a fusion protein having an amino-terminal portion encoded by an angiotensin II, type I receptor-associated protein (AGTRAP) gene and a carboxy-terminal portion encoded by a kinase domain of a RAF family member gene.

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