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Method of treating rheumatoid arthritis using antibody to IL6R

  • US 8,945,560 B1
  • Filed: 08/12/2014
  • Issued: 02/03/2015
  • Est. Priority Date: 07/15/2014
  • Status: Active Grant
First Claim
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1. A method of treating or reducing the risk of rheumatoid arthritis in a human in need thereof, the method comprising administering to said human an antibody or antibody fragment that specifically binds an IL6R protein that comprises a mutation Asp358Ala or Val385Ile in SEQ ID NO:

  • 78,wherein the antibody or antibody fragment comprises a human gamma-1 heavy chain constant region that comprises an amino acid selected from the group consisting of;

    an Asp at position 204 shown in SEQ ID NO;

    81 and a Leu at position 206 shown in SEQ ID NO;

    81;

    andwherein said human comprises(i) an IGHG1*01 human heavy chain constant region gene segment,or the human expresses antibodies comprising human gamma-1 heavy chain constant regions comprising said selected amino acid and(ii) a nucleotide sequence encoding said IL6R protein comprising said Asp358Ala or Val385Ile in SEQ ID NO;

    78.

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