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Capsules containing high doses of levodopa for pulmonary use

  • US 8,945,612 B2
  • Filed: 02/06/2014
  • Issued: 02/03/2015
  • Est. Priority Date: 11/09/2012
  • Status: Active Grant
First Claim
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1. A capsule for use in an inhalation device filled with a dry powder comprising levodopa, a salt and a phospholipid and having a working density between about 0.02 to about 0.1 g/cm3, and containing a capsule shell comprising hydroxypropyl methylcellulose (HPMC) and titanium dioxide, and wherein said capsule emits more powder comprising levodopa upon actuation of the inhalation device as compared to a capsule that comprises HPMC and is free of titanium dioxide;

  • and wherein the capsule comprises from about 80% to about 95% levodopa.

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