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Intrabuccally rapidly disintegrating tablet and a production method of the tablets

  • US 8,945,618 B2
  • Filed: 03/13/2014
  • Issued: 02/03/2015
  • Est. Priority Date: 06/14/1996
  • Status: Expired due to Fees
First Claim
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1. A method of producing an intrabuccally rapidly disintegrating tablet, said intrabuccally rapidly disintegrating tablet comprising:

  • a sugar alcohol or saccharide in the form of primary particles having an average particle size of not more than 30 μ

    m;

    an active ingredient; and

    one or more disintegrants selected from the group consisting of crosspovidone, crosscarmellose sodium, low substituted hydroxypropylcellulose, and a mixture thereof, said method comprising the steps of;

    (a) mixing a powder material comprising the sugar alcohol or saccharide, said active ingredient and said one or more disintegrants;

    (b) granulating the mixture of step (a), thereby producing granulated material having a predetermined particle size; and

    (c) compressing the granulated mixture into an intrabuccally rapidly disintegrating tablet.

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