Modified insulin polypeptides and their uses

• US 8,946,148 B2
• Filed: 11/20/2008
• Issued: 02/03/2015
• Est. Priority Date: 11/20/2007
• Status: Expired due to Fees

• Current Assignee: Ambrx, Inc. (Johnson & Johnson)
• Original Assignee: Ambrx, Inc. (Johnson & Johnson)
• Inventors: Miao, Zhenwei, Krawitz, Denise, Kraynov, Vadim, Tian, Feng, Sim, Bee-Cheng, Skidmore, Lillian, Hays Putnam, Anna-Maria A., Knudsen, Nick, Deguzman, Michael
• Primary Examiner(s): Saoud, Christine J
• Application Number:
  US12/740,619
• Publication Number:
  US 20100298212A1
• Time in Patent Office: 2,266 Days
• Field of Search: None
• US Class Current: 514/6.3
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61K 38/28 Insulins
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/06 Antihyperlipidemics
• CPC Class Codes: A61P 3/08 for glucose homeostasis pancreatic hormones A61P5/48
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: C07K 14/62 Insulins

Abstract

Modified insulin polypeptides and their uses thereof are provided.

Claims

1. An insulin polypeptide comprising a para-acetyl-phenylalanine

2. The insulin polypeptide of claim 1 wherein the A chain comprises a glycine at position 21.

3. The insulin polypeptide of claim 1 wherein the polypeptide comprises an additional substitution with one of the 20 common amino acids.