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Treatment of interferon regulatory factor 8 (IRF8) related diseases by inhibition of natural antisense transcript to IRF8

  • US 8,946,181 B2
  • Filed: 01/04/2011
  • Issued: 02/03/2015
  • Est. Priority Date: 01/04/2010
  • Status: Active Grant
First Claim
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1. A method of upregulating a function of and/or the expression of a Interferon Regulatory Factor 8 (IRF8) polynucleotide in patient cells or tissues in vivo or in vitro comprising:

  • contacting said cells or tissues with at least one modified antisense oligonucleotide 12 to 30 nucleotides in length wherein said at least one oligonucleotide is specific for and targets a natural antisense polynucleotide of the IRF8 gene and has identity to a reverse complement of a polynucleotide comprising 12 to 30 consecutive nucleotides within nucleotides 1 to 312 of SEQ ID NO;

    2 thereby upregulating a function of and/or the expression of the Interferon Regulatory Factor 8 (IRF8) polynucleotide in patient cells or tissues in vivo or in vitro.

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