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FcγRIIB specific antibodies and methods of use thereof

  • US 8,946,387 B2
  • Filed: 08/05/2008
  • Issued: 02/03/2015
  • Est. Priority Date: 08/14/2002
  • Status: Expired due to Fees
First Claim
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1. A bispecific antibody comprising:

  • (A) a first antigen binding polypeptide that selectively binds Fcγ

    RIIB and comprises CDR1, CDR2 and CDR3 from an antibody heavy chain, and CDR1, CDR2 and CDR3 from an antibody light chain, wherein;

    (1) said light chain CDR1 has a sequence of SEQ ID NO;

    36, said light chain CDR2 has a sequence of SEQ ID NO;

    37, and said light chain CDR3 has a sequence of SEQ ID NO;

    38; and

    (2) said heavy chain CDR1 has a sequence of SEQ ID NO;

    27, said heavy chain CDR2 has a sequence of SEQ ID NO;

    28, and said heavy chain CDR3 has a sequence of SEQ ID NO;

    29,and said first antigen binding polypeptide has the binding characteristics of an antibody produced from a hybridoma cell line having ATCC accession number PTA-4592; and

    (B) a second antigen binding polypeptide, that specifically binds an activating receptor.

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