Millimeter wave 3-D breast imaging

• US 8,948,847 B2
• Filed: 05/09/2013
• Issued: 02/03/2015
• Est. Priority Date: 05/11/2012
• Status: Active Grant

• Current Assignee: Tufts University
• Original Assignee: Tufts University
• Inventors: Afsar, Mohammed N., Chao, Liu
• Primary Examiner(s): ROZANSKI, MICHAEL T
• Application Number:
  US13/890,336
• Publication Number:
  US 20130303901A1
• Time in Patent Office: 635 Days
• Field of Search: 600/430, 600/407, 600/310, 600/473, 600/476, 600/438, 600/442, 600/2, 606/2, 606/12, 606/33, 128/915, 607/100, 607/101, 356/479
• US Class Current: 600/430
• CPC Class Codes: A61B 5/0507 using microwaves or terahertz waves
• CPC Class Codes: A61B 5/4312 Breast evaluation or disorder diagnosis A61B5/0091 takes precedence
• CPC Class Codes: G06T 11/00 2D [Two Dimensional] image generation
• CPC Class Codes: H01Q 13/02 Waveguide horns
• CPC Class Codes: H01Q 19/08 for modifying the radiation pattern of a radiating horn in which it is located corrugated horns H01Q13/0208; producing a circular polarisation H01Q13/0241
• CPC Class Codes: H01Q 19/12 wherein the surfaces are concave H01Q19/18 takes precedence
• CPC Class Codes: H01Q 3/00 Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system means for positioning H01Q1/125

Abstract

A system for imaging tissue includes a millimeter wave Quasi-optical backward wave oscillator. Tumorous tissue is detected in a reconstructed image using solvable inverse image reconstruction techniques. In one embodiment, three-dimensional breast imaging is enabled by providing radiation as a focused energy beam over a wide frequency range and at power levels to penetrate breast tissue disposed within dielectric compression plates.

Claims

1. A method for imaging tissue comprising:

providing a quasi-optical millimeter wave spectrometer having millimeter wave radiation from a backward-wave oscillator (BWO);

modulating the radiation using a ferrite modulator;

transforming the modulated radiation into a paraxial Gaussian beam;

compressing the tissue between a pair of dielectric compression plates;

transmitting the paraxial Gaussian beam through the compressed tissue; and

detecting tissue image amplitude and phase data as a function of frequency.

2. The method of claim 1 further comprising processing the detected imaged data using total variation regularization.

3. The method of claim 2 wherein processing the detected imaged data using total variation regularization comprises using Tikhonov regularization.

4. The method of claim 1 wherein the millimeter wave radiation from the BWO is in a frequency range of approximately 30 GHz to approximately 120 GHz.

5. The method of claim 4 further comprising energizing the quasi-optical spectrometer by tuning at least one BWO tube.

6. The method of claim 4, wherein the millimeter wave radiation from the BWO is in a power range of approximately 20 mW to approximately 40 mW.

7. The method of claim 1 further comprising:

reconstructing a 3-D image; and

displaying the reconstructed 3-D image.

8. The method of claim 7, wherein reconstructing the 3-D image comprises:

generating a plurality of projections from different directions; and

rendering a three dimensional image of the tissue, wherein pixels in the plurality of projections represent an accumulation of attenuation from the tissue.

9. The method of claim 8, wherein generating the plurality of projections comprises determining a line integral of complex permittivity;

and

repeating determining line integrals on parallel lines.

10. A system for imaging tissue comprising:

a millimeter wave radiation source;

a waveguide coupled to the radiation source;

an isolator coupled to the waveguide;

a modulator coupled to the isolator;

a first antenna coupled to the modulator;

a first focusing device coupling radiation from the first antenna to a first compression plate;

a second compression plate aligned with the first compression plate to form an aperture configured for receiving the tissue;

wherein the modulator comprises a ferrite modulator and the millimeter wave radiation source comprises a backward-wave oscillator (BWO); and

wherein the first antenna is configured for transforming millimeter wave radiation from the millimeter wave radiation source into a Gaussian beam.

11. The system of claim 10 further comprising:

a second focusing device receiving radiation passing through the first and second compression plates;

a second antenna directing radiation from the second focusing device; and

a detector aligned to receive radiation directed from the second antenna.

12. The system of claim 11, wherein the first focusing device and the second focusing device comprise lens assemblies.

13. The system of claim 11, wherein the first focusing device and the second focusing device comprise parabolic mirror assemblies and the first antenna comprises a horn antenna.

14. The system of claim 11 further comprising:

a first directional coupler disposed between the modulator and the first antenna; and

a second directional coupler disposed between the second antenna and the detector.

15. The system of claim 14 further comprising an attenuator disposed between the first directional coupler and the second directional coupler.

16. The system of claim 10, wherein the BWO provides radiation over a frequency range of approximately 30 GHz to approximately 120 GHz and over a power range of approximately 20 mW to approximately 40 mW.

17. The system of claim 10 further comprising an image processor using Total Variation regularization.

18. The system of claim 10 further comprising a rotating base disposed to rotate the millimeter wave radiation source, the waveguide, the isolator, the modulator, the antenna and the first focusing device around the first and second compression plates.

19. The system of claim 10, wherein the Gaussian beam is a paraxial Gaussian beam.

20. A non-transitory computer readable storage medium for tangibly storing thereon computer readable instructions for a method comprising:

providing a quasi-optical millimeter wave spectrometer having a millimeter wave radiation from a backward-wave oscillator (BWO);

modulating the radiation using a ferrite modulator;

transforming the modulated radiation into a paraxial Gaussian beam;

compressing tissue between a pair of dielectric compression plates;

transmitting the paraxial Gaussian beam through the compressed tissue; and

detecting tissue image amplitude and in phase data as a function of frequency.