Treatment of obstructive disorders of the eye or eyelid

• US 8,950,405 B2
• Filed: 10/30/2007
• Issued: 02/10/2015
• Est. Priority Date: 05/15/2006
• Status: Active Grant

• Current Assignee: TearScience Inc. (Johnson & Johnson)
• Original Assignee: TearScience Inc. (Johnson & Johnson)
• Inventors: Grenon, Stephen M., Korb, Donald R., Willis, Timothy R.
• Primary Examiner(s): ROANE, AARON F
• Application Number:
  US11/928,681
• Publication Number:
  US 20080046048A1
• Time in Patent Office: 2,660 Days
• Field of Search: 128/898, 607/96
• US Class Current: 128/898
• CPC Class Codes: A61B 17/22 Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for dilators A61M29/00
• CPC Class Codes: A61B 17/22004 using mechanical vibrations, e.g. ultrasonic shock waves A61B17/225 takes precedence
• CPC Class Codes: A61F 2007/0004 Eyes or part of the face surrounding the eyes
• CPC Class Codes: A61F 2007/0261 medicated
• CPC Class Codes: A61F 7/02 Compresses or poultices for effecting heating or cooling
• CPC Class Codes: A61F 9/00772 Apparatus for restoration of tear ducts

Abstract

In accordance with certain illustrative embodiments, methods and apparatuses of treating obstructive disorders of the structure of an eye or eyelid are disclosed. The treating may involve applying heat to the structure containing the obstructive disorder to melt an obstruction in the structure and place the obstruction in a melted state. The heat may be maintained for a time period to melt the obstruction and place the obstruction in the melted state. The structure may be treated by expressing the melted obstruction from the structure. The treating may be carried out either during the time period or after the time period when heat is applied but while the obstruction is in the melted state. In certain embodiments, the method further involves subsequently treating the structure by use of a pharmacological agent. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.

Claims

1. A method of treating obstructive disorders of a meibomian gland channel of an eyelid, comprising:

applying regulated heat to a channel of a meibomian gland of an eyelid containing the obstructive disorder that reaches a temperature to melt at least one obstruction in the channel and place the at least one obstruction in a melted state;

maintaining the heat for a time period to melt the at least one obstruction and place the at least one obstruction in a melted state; and

expressing the at least one obstruction from the channel and through an orifice of the meibomian gland by applying a milking action to the channel, wherein the expressing is carried out while the at least one obstruction is in the melted state.

2. The method according to claim 1, further comprising subsequently treating the eyelid by use of a pharmacological agent.

3. The method according to claim 1, wherein the time period comprises approximately 1 to 60 minutes.

4. The method according to claim 1, wherein the expressing is carried out using a heated instrument.

5. The method according to claim 1, wherein the temperature reaches between approximately 42 and 47 degrees Celsius.

6. The method according to claim 1, wherein the expressing is carried out within approximately 3 minutes after the end of the time period.

7. The method according to claim 1, wherein the pharmacological agent comprises at least one of a topical pharmacological agent and a systemic pharmacological agent.

8. The method according to claim 1, wherein the pharmacological agent is selected from the group consisting of anti-inflammatory agents, antibiotics, topical tetracycline, oral tetracycline, topical corticosteroids, oral corticosteroids, topical androgens, topical androgen analogues, TGF-β

, omega 3 compounds, enzymes that promote lipid production, agents that stimulate production of enzymes that promote lipid production, agents that act as a secretagogue to enhance Meibomian gland secretion, and agents that replace or promote production of any tear component.

9. The method according to claim 1, further comprising repeating at least one of the applying and maintaining of regulated heat after a time interval to maintain flow of fluids from the channel and the expressing at the time interval to maintain flow of fluids from the channel.

10. The method according to claim 1, wherein the obstructive disorder comprises a disorder selected from the group consisting of chalazion, hordeolum, pimples, blackheads and styes.

11. The method of claim 1, wherein the expressing is carried out either during the time period or after the time period.

26. The method of claim 1, wherein the applying a milking action comprises applying a regulated directional force to the channel in a direction from a bottom of the channel to a top of the channel.

12. A method of treating obstructive disorders of a meibomian gland channel of an eyelid, comprising:

applying a regulated heat of at least approximately 37 degrees Celsius to an eye or eyelid containing the disorder to a temperature to melt at least one obstruction in the channel and place the at least one obstruction in a melted state;

maintaining the heat for a time period to melt the at least one obstruction and place the at least one obstructions in a melted state, and wherein the time period is between approximately 1 and 60 minutes;

expressing the at least one obstruction from the channel and through an orifice of the meibomian gland by applying a milking action to the channel, wherein the treating is carried out while the at least one obstruction is in the melted state; and

subsequently pharmacologically treating the eyelid by use of a pharmacological agent.

13. The method according to claim 12, wherein the temperature reaches approximately 42 to 47 degrees Celsius.

14. The method according to claim 12, wherein the expressing further comprises one or more of:

applying vibratory stimulation to the eyelid, squeezing the eyelid, applying constant pressure to the eyelid, or applying pulsating pressure to the eyelid.

15. The method according to claim 12, wherein the pharmacological agent comprises at least one of a topical pharmacological agent and a systemic pharmacological agent.

16. The method according to claim 12, wherein the expressing is carried out using a heated instrument.

17. The method according to claim 12, wherein the pharmacological agent is selected from the group consisting of anti-inflammatory agents, antibiotics, topical tetracycline, oral tetracycline, topical corticosteroids, oral corticosteroids, topical androgens, topical androgen analogues, TGF-β

, omega 3 compounds, enzymes that promote lipid production, agents that stimulate production of enzymes that promote lipid production, agents that act as a secretagogue to enhance Meibomian gland secretion, and agents that replace or promote production of any tear component.

18. The method according to claim 12, wherein the obstructive disorder is selected from the group consisting of chalazion, hordeolum, pimples, blackheads, and styes.

19. The method according to claim 12, wherein the expressing is carried out prior to approximately 90 seconds after expiration of the time period.

27. The method of claim 12, wherein the applying a milking action comprises applying a regulated directional force to the channel in a direction from a bottom of the channel to a top of the channel.

20. A method of treating obstructive disorders of a channel of an eye or eyelid including chalazion, hordeolum, pimples, blackheads, and styes, comprising:

applying a regulated heat in the range of approximately 42 to 47 degrees Celsius to an eyelid containing the structure to a temperature to melt at least one obstruction in the channel and place the at least one obstruction in a melted state;

maintaining the heat for a time period to melt the at least one obstruction and place the at least one obstruction in the melted state, wherein the time period is between approximately 1 and 60 minutes;

expressing fluid or suspension from the channel and through an orifice at an end of the channel by applying a milking action to the channel, wherein the expressing is carried out either during the time period or within approximately 90 seconds following the end of the time period while the at least one obstruction is in the melted state, wherein the expressing is carried out using a heated instrument; and

subsequently, pharmacologically treating the eye or eyelid by use of a pharmacological agent.

21. The method according to claim 20, wherein the expressing further comprises one or more of:

applying mechanical energy stimulation to the eyelid, applying vibratory energy to the eyelid, squeezing the eyelid, applying constant pressure, or applying pulsating pressure to the eyelid.

22. The method according to claim 20, wherein the pharmacological agent comprises at least one of a topical pharmacological agent and a systemic pharmacological agent.

28. The method of claim 20, wherein the applying a milking action comprises applying a regulated directional force to the channel in a direction from a bottom of the channel to a top of the channel.

23. A method of treating obstructive disorders of a channel of the eye or eyelid including chalazion, hordeolum, pimples, blackheads, and styes in which at least one obstruction blocks flow of fluid from the channel, comprising:

applying a regulated heat source proximate to the channel for a selected time and at a selected temperature adequate to melt at least a portion of the at least one obstruction;

applying a milking action to the channel while the at least a portion of the at least one obstruction is melted such that at least a portion of the at least one obstruction is removed from the channel through an orifice at an end of the channel;

subsequently treating the disorder with a pharmacological agent.

24. The method according to claim 23, wherein the selected temperature reaches between approximately 42 and 47 degrees Celsius.

25. The method according to claim 23, wherein the pharmacological agent comprises at least one of a topical pharmacological agent and a systemic pharmacological agent.

29. The method of claim 23, wherein the applying a milking action comprises applying a regulated directional force to the channel in a direction from a bottom of the channel to a top of the channel.