Methods and apparatus for isolating platelets from blood
First Claim
1. A blood platelet collection device, comprising:
- a container that partially defines a volume by a sidewall extending from a first end to a second end;
a float moveably positioned in the volume, the float having a concave collection surface;
a plunger positioned between the float and the first end and the plunger is substantially axially concentric with the float within the volume;
a closure at the first end of the container;
a first access port having a first port passage that is formed at least in part by a first sidewall extending from the closure and is formed through the closure; and
a second access port having a second port passage that is formed at least in part by a second sidewall extending from the closure and is formed through the closure;
wherein the first access port is configured to allow blood to be introduced into the container and wherein the second access port is configured to allow sedimented platelets to be withdrawn from the container.
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Abstract
A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
587 Citations
18 Claims
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1. A blood platelet collection device, comprising:
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a container that partially defines a volume by a sidewall extending from a first end to a second end; a float moveably positioned in the volume, the float having a concave collection surface;
a plunger positioned between the float and the first end and the plunger is substantially axially concentric with the float within the volume;a closure at the first end of the container; a first access port having a first port passage that is formed at least in part by a first sidewall extending from the closure and is formed through the closure; and a second access port having a second port passage that is formed at least in part by a second sidewall extending from the closure and is formed through the closure; wherein the first access port is configured to allow blood to be introduced into the container and wherein the second access port is configured to allow sedimented platelets to be withdrawn from the container. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 17)
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9. A blood platelet collection device, comprising:
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a container having a longitudinal inner surface defining a volume; a movable separation member positioned within the container, the separation member including a first member and a second member separated by a collection cavity, the first member defining a first member passage through the first member to the collection cavity and the second member defines a concave collection surface in the collection cavity; and a port having a fixed sidewall that forms an internal port passage that extends through a closure of the container, wherein the port is configured to allow fluid to be withdrawn from the collection cavity, through the first member passage in the first member and out of the port. - View Dependent Claims (10, 11, 18)
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12. A blood platelet collection device, comprising:
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a container defining a volume within a sidewall, a first end closure, and a second end closure; a movable separation member positioned within the container, the moveable separation member including a first member and a second member separated by third member, a collection cavity defined between the first member and the second member within the volume and the second member defines a concave collection surface in the collection cavity; and a port formed by a fixed sidewall defining a passage through the first end closure, wherein the port is configured to allow access to the volume from exterior to the container, wherein a fluid can be withdrawn from the collection cavity though the port. - View Dependent Claims (13, 14, 15, 16)
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Specification