Ostial renal nerve ablation

• US 8,951,251 B2
• Filed: 11/07/2012
• Issued: 02/10/2015
• Est. Priority Date: 11/08/2011
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Willard, Martin R.
• Primary Examiner(s): Manuel, George
• Application Number:
  US13/671,244
• Publication Number:
  US 20130116687A1
• Time in Patent Office: 825 Days
• Field of Search: 606/41
• US Class Current: 606/41
• CPC Class Codes: A61B 18/082 Probes or electrodes therefor
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2018/0022 Balloons
• CPC Class Codes: A61B 2018/00267 having a basket shaped structure
• CPC Class Codes: A61B 2018/00375 Ostium, e.g. ostium of pulmonary vein or artery
• CPC Class Codes: A61B 2018/00404 Blood vessels other than those in or around the heart
• CPC Class Codes: A61B 2018/00434 Neural system
• CPC Class Codes: A61B 2018/00511 Kidney
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61N 2007/003 Destruction of nerve tissue
• CPC Class Codes: A61N 7/022 intracavitary
• CPC Class Codes: F04C 2270/041 Controlled or regulated

Abstract

A catheter including an elongated shaft having a distal end and a proximal end, where the catheter includes a thermal element at the distal end thereof. The thermal element may be used in an ablation procedure or other procedure to heat a tissue adjacent a vessel. In some instances, the thermal element may be positioned in a first vessel and may operate to heat tissue adjacent a second vessel or adjacent an ostium between the first vessel and the second vessel. Further, the catheter may include an expandable portion on which the thermal element may be connected or positioned. The expandable portion(s) may comprise a basket or cage, a balloon, a memory shape and formable portion, and/or other mechanical expanders.

Claims

1. An ablation catheter apparatus for inserting into a lumen of a first vessel of a body of a patient where a second vessel extends from the first vessel and forms an ostium with the first vessel, the ablation catheter apparatus comprising:

an elongated member having a distal end with a first terminal end and a proximal end with a second terminal end, where the elongated member has a length measured from the first terminal end to the second terminal end;

a guide wire extending substantially the length of the elongated member and extendable through the first terminal end;

an electrically conductive wire having a distal end and a proximal end, where the electrically conductive wire extends substantially the length of the elongated member; and

a thermal element connected to the distal end of the electrically conductive wire;

wherein the thermal element is configured to facilitate ablation of a perivascular tissue adjacent the second vessel from a position within the first vessel.

2. The ablation catheter apparatus of claim 1, wherein the thermal element is positionable in the first vessel while the guide wire extends into the second vessel.

3. The ablation catheter apparatus of claim 2, wherein the guide wire is a ground electrode configured to complete an electrical path from the thermal element through the ostium to the guide wire to ablate nerve tissue proximate the ostium.

4. The ablation catheter apparatus of claim 3, wherein the thermal element is configured to direct electrical energy along a localized electrical pathway between the thermal element and the guidewire to ablate nerve tissue proximate the ostium, without having to complete an electrical pathway to an exterior of the patient'"'"'s body.

5. The ablation catheter apparatus of claim 1, further comprising:

a sheath forming a lumen through which the elongated member extends; and

wherein the sheath is retractable; and

wherein the thermal element is exposed and is configured to abut an ostium between the first vessel and the second vessel when the sheath is retracted.

6. The ablation catheter apparatus of claim 1, further comprising:

an expandable feature positioned at the distal end of the elongated member; and

a plurality of thermal elements connected to the expandable feature;

wherein the plurality of thermal elements are configured to be arranged around the ostium between the first vessel and the second vessel.

7. The ablation catheter apparatus of claim 6, wherein the expandable feature is an expandable cage positioned adjacent the distal end of the elongated member configured to expand from a first position to a second position.

8. The ablation catheter apparatus of claim 6, wherein the expandable feature is a balloon mounted on the elongated member configured to be inflated from a first position to a second position.

9. A method of ablating a perivascular tissue, comprising:

positioning an elongated shaft in a first vessel lumen of a first vessel, where the elongated shaft includes a distal end and a proximal end; and

heating a perivascular tissue at a target area adjacent a second vessel with a thermal element positioned in the first vessel at the distal end of the elongated shaft.

10. The method of claim 9, further comprising:

expanding an expandable portion of the distal end of the elongated shaft, the thermal element being connected to the expandable portion; and

positioning the expanded expandable portion adjacent an ostium between the first vessel and the second vessel.

11. The method of claim 10, further comprising:

positioning a guide wire extending through the elongated shaft into the second vessel with the expandable portion of the distal end of the elongated shaft positioned in the first vessel.

12. The method of claim 11, wherein the guide wire is a ground electrode and the thermal element is an ablation electrode;

and

directing electrical energy along a localized electrical pathway between the ablation electrode positioned in the first vessel and the guidewire positioned in the second vessel to ablate the perivascular tissue proximate the ostium.

13. The method of claim 9, further comprising

heating the perivascular tissue at multiple target areas at multiple distinct locations adjacent the second vessel.

14. The method of claim 13, wherein the perivascular tissue at the multiple target areas at the multiple distinct locations adjacent the second vessel are simultaneously heated with a different thermal element positioned in the first vessel at the distal end of the elongated shaft.

15. The method of claim 13, wherein the perivascular tissue at the multiple target areas at the multiple distinct locations are sequentially heated.

16. An ablation method using a catheter having an elongated shaft with a distal end and a proximal end, a guide wire extending through the elongated shaft, and at least one thermal element connected to an expandable feature positioned adjacent the distal end of the elongated shaft, the method comprising:

positioning the distal end of the elongated shaft and the thermal element in a first vessel;

expanding the expandable feature to position the thermal element adjacent an ostium between the first vessel and a second vessel; and

conveying energy from the thermal element positioned in the first vessel through the ostium and a perivascular tissue adjacent the second vessel.

17. The method of claim 16, further comprising:

positioning the guide wire in the second vessel; and

conveying the energy from the thermal element to the guide wire positioned in the second vessel after the energy is conveyed through the perivascular tissue; and

wherein the guide wire is configured as a ground electrode and the thermal element is configured as an ablation electrode.

18. The method of claim 17, further comprising:

energizing the ablation electrode in a bipolar arrangement with the ground electrode.

19. The method of claim 17, wherein the expandable feature includes a plurality of thermal elements circumferentially spaced about and connected to an exterior thereof, wherein the conveying energy step comprises simultaneously conveying energy from the plurality of thermal elements through the ostium and the perivascular tissue.

20. The method of claim 17, wherein the expandable portion includes a plurality of thermal elements circumferentially spaced about and connected to an exterior thereof;

and

wherein the conveying energy step comprises sequentially conveying energy from the plurality of thermal elements through the ostium and the perivascular tissue.