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Methods of promoting angiogenesis using cerium oxide nanoparticles

  • US 8,951,539 B1
  • Filed: 06/07/2012
  • Issued: 02/10/2015
  • Est. Priority Date: 06/07/2011
  • Status: Active Grant
First Claim
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1. A method of promoting angiogenesis in animal tissue, the method comprising contacting the tissue with a composition comprising cerium oxide nanoparticles effective for stimulating proliferation of endothelial cells associated with the tissue;

  • wherein the cerium oxide nanoparticles are spherical with a diameter of about 3 nm to about 5 nm; and

    wherein the cerium oxide nanoparticles have a surface and a concentration of Ce(3+) greater than a concentration of Ce(4+) at the surface.

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