Methods of promoting angiogenesis using cerium oxide nanoparticles
First Claim
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1. A method of promoting angiogenesis in animal tissue, the method comprising contacting the tissue with a composition comprising cerium oxide nanoparticles effective for stimulating proliferation of endothelial cells associated with the tissue;
- wherein the cerium oxide nanoparticles are spherical with a diameter of about 3 nm to about 5 nm; and
wherein the cerium oxide nanoparticles have a surface and a concentration of Ce(3+) greater than a concentration of Ce(4+) at the surface.
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Abstract
Methods of using cerium oxide nanoparticles to promote angiogenesis are described. In a particular embodiment, a method of promoting angiogenesis in animal tissue comprises contacting the tissue with a composition comprising cerium oxide nanoparticles effective for stimulating proliferation of endothelial cells associated with the tissue.
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Citations
9 Claims
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1. A method of promoting angiogenesis in animal tissue, the method comprising contacting the tissue with a composition comprising cerium oxide nanoparticles effective for stimulating proliferation of endothelial cells associated with the tissue;
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wherein the cerium oxide nanoparticles are spherical with a diameter of about 3 nm to about 5 nm; and wherein the cerium oxide nanoparticles have a surface and a concentration of Ce(3+) greater than a concentration of Ce(4+) at the surface. - View Dependent Claims (2, 3)
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4. A method of promoting angiogenesis, the method comprising administering cerium oxide nanoparticles to a patient having a physiological condition that can be remediated by increasing endothelial cell proliferation;
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wherein the cerium oxide nanoparticles are spherical with a diameter of about 3 nm to about 5 nm; and wherein the cerium oxide nanoparticles have a surface and a concentration of Ce(3+) greater than a concentration of Ce(4+) at the surface. - View Dependent Claims (5, 6)
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7. A method of promoting angiogenesis in a patient having a condition that can be remediated by increasing endothelial cell proliferation, the method comprising contacting a tissue of the patient with cerium oxide nanoparticles in an amount sufficient to transiently lower an intracellular oxygen concentration of the tissue, wherein the transient lowering the intracellular oxygen concentration stimulates expression of HIF1α
- , promotes proliferation of endothelial cells, and promotes angiogenesis in the tissue;
wherein the cerium oxide nanoparticles are spherical with a diameter of about 3 nm to about 5 nm; and wherein the cerium oxide nanoparticles have a surface and a concentration of Ce(3+) greater than a concentration of Ce(4+) at the surface. - View Dependent Claims (8, 9)
- , promotes proliferation of endothelial cells, and promotes angiogenesis in the tissue;
Specification