Compositions for topical treatment

• US 8,951,582 B2
• Filed: 11/02/2013
• Issued: 02/10/2015
• Est. Priority Date: 05/15/2013
• Status: Active Grant

• Current Assignee: Normajean Fusco
• Original Assignee: Normajean Fusco
• Inventors: Fusco, Normajean
• Primary Examiner(s): MELLER, MICHAEL V
• Application Number:
  US14/070,486
• Publication Number:
  US 20140343158A1
• Time in Patent Office: 465 Days
• Field of Search: None
• US Class Current: 424/725
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A01N 31/14 Ethers
• CPC Class Codes: A01N 33/12 Quaternary ammonium compounds
• CPC Class Codes: A01N 37/36 containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
• CPC Class Codes: A01N 39/00 Biocides, pest repellants or attractants, or plant growth regulators containing aryloxy- or arylthio-aliphatic or cycloaliphatic compounds, containing the group or , e.g. phenoxyethylamine, phenylthio-acetonitrile, phenoxyacetone
• CPC Class Codes: A01N 47/44 Guanidine; Derivatives thereof
• CPC Class Codes: A61K 31/045 Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
• CPC Class Codes: A61K 31/14 Quaternary ammonium compounds, e.g. edrophonium, choline betaines A61K31/205
• CPC Class Codes: A61K 31/155 Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
• CPC Class Codes: A61K 31/22 of acyclic acids, e.g. pravastatin
• CPC Class Codes: A61K 36/185 Magnoliopsida (dicotyledons)
• CPC Class Codes: A61K 36/28 Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
• CPC Class Codes: A61K 8/34 Alcohols
• CPC Class Codes: A61K 8/342 Alcohols having more than seven atoms in an unbroken chain
• CPC Class Codes: A61K 8/361 Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
• CPC Class Codes: A61K 8/37 Esters of carboxylic acids
• CPC Class Codes: A61K 8/416 Quaternary ammonium compounds A61K8/35 takes precedence
• CPC Class Codes: A61K 8/43 Guanidines
• CPC Class Codes: A61K 8/463 containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
• CPC Class Codes: A61K 8/84 : obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
• CPC Class Codes: A61K 8/891 : saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
• CPC Class Codes: A61K 8/9789 : Magnoliopsida [dicotyledons]
• CPC Class Codes: A61K 8/9794 : Liliopsida [monocotyledons]
• CPC Class Codes: A61Q 17/005 : Antimicrobial preparations

Abstract

A stable, self-preserving, antimicrobial, composition suitable for the treatment of a variety of dermal as well as subcutaneous conditions. The compositions include as an active ingredient a quaternary ammonium compound, preferably benzethonium chloride, potentiated and synergized with menthyl lactate cooling agent in a cationic carrier. Optionally, a phenoxyethanol preservative and chlorhexidine digluconate antibacterial agent may be used to assist in enhancing the activity. The compositions kill a broad spectrum of gram-negative and gram-positive bacteria, fungus and yeasts. The compositions are used as first aid skin treatments and as skin sanitizers to help prevent bacterial contamination of minor cuts, scrapes and burns. The compositions are particularly useful when applied to the skin after hair removal in that they additionally cool, soothe and moisturize the skin. The compositions may also serve as a base vehicle in which additional skin care ingredients may be added to provide additional functionality to the compositions.

Claims

1. A method of treating bacterial contamination in the skin of a human in need thereof consisting essentially of administering to the skin of the human a stable, antimicrobial composition consisting essentially of:

i. a cationic thickener selected from the group consisting of Polyquaternium, chitosan, hydroxyethyl cetyldimonium phosphate, and guar hydroxypropyltrimonium Chloride; and

ii. a cationic conditioning agent and emulsifier which are selected from the group consisting of behentrimonium methosulfate, cetrimonium chloride, myristamidopropyl PG-dimonium chloride phosphate, brassicyl isoleucinate esylate, Incroquat behenyl TMS, Incroquat behenyl TMS 50, cetrimonium chloride, distearyldimonium chloride, and stearalkonium chloride; and

iii. an effective antimicrobial amount of a component selected from the group consisting of polyhexamethylene biguanide, polyaminopropyl biguanide, alexidine, benzalkonium chloride, benzethonium chloride, methylbenzethonium chloride, cetrimonium chloride, and lysine; and

iv. an amount of a menthol-based cooling agent.

2. The method of claim 1, wherein the amount of the menthol based cooling agent in the antimicrobial composition is between 0.1 to 7.0% by weight.

3. The method of claim 1, wherein the effective antimicrobial amount of the antimicrobial agent is between 0.01% to 5% by weight.

4. The method of claim 1, wherein the antimicrobial agent is selected from the group consisting of:

b. Benzethonium chloride wherein the effective antimicrobial amount is from 0.01 to 0.2% w/w;

c. Benzalkonium chloride wherein the effective antimicrobial amount is from 0.01 to 0.13% w/w; and

d. Methylbenzethonium chloride wherein the effective antimicrobial amount is 0.01 to 0.5% w/w.

5. A method of treating bacterial contamination in the skin of a human in need thereof consisting essentially of administering to the skin of the human a therapeutically effective amount of a stable, antimicrobial composition consisting essentially of:

i. a cationic thickener selected from the group consisting of Polyquaternium, chitosan, hydroxyethyl cetyldimonium phosphate, and guar hydroxypropyltrimonium Chloride; and

ii. a cationic conditioning agent and emulsifier which are selected from the group consisting of behentrimonium methosulfate, cetrimonium chloride, myristamidopropyl PG-dimonium chloride phosphate, brassicyl isoleucinate esylate, Incroquat behenyl TMS, Incroquat behenyl TMS 50, cetrimonium chloride, distearyldimonium chloride, and stearalkonium chloride; and

iii. an effective antimicrobial amount of a component selected from the group consisting of polyhexamethylene biguanide, polyaminopropyl biguanide, alexidine, benzalkonium chloride, benzethonium chloride, methylbenzethonium chloride, cetrimonium chloride, and lysine;

iv. an amount of a menthol-based cooling agent and;

v. a non-ionic thickener.

6. A method of treating bacterial contamination in the skin of a human in need thereof consisting essentially of administering to the skin of the human a therapeutically effective amount of a stable antimicrobial composition consisting essentially of:

i. a cationic thickener selected from the group consisting of Polyquaternium, chitosan, hydroxyethyl cetyldimonium phosphate, and guar hydroxypropyltrimonium Chloride; and

ii. a cationic conditioning agent and emulsifier which are selected from the group consisting of behentrimonium methosulfate, cetrimonium chloride, myristamidopropyl PG-dimonium chloride phosphate, brassicyl isoleucinate esylate, Incroquat behenyl TMS, Incroquat behenyl TMS 50, cetrimonium chloride, distearyldimonium chloride, and stearalkonium chloride; and

iii. an effective antimicrobial amount of a component selected from the group consisting of polyhexamethylene biguanide, polyaminopropyl biguanide, alexidine, benzalkonium chloride, benzethonium chloride, methylbenzethonium chloride, cetrimonium chloride, and lysine; and

iv. an amount of a menthol-based cooling agent and;

v. an amount of a non-ionic conditioning agent and a non-ionic emulsifying agent.