Coatings with tunable molecular architecture for drug-coated balloon
First Claim
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1. A method of coating an outer surface of a balloon of a balloon catheter, the method comprising:
- selecting a first therapeutic agent;
selecting a first excipient;
modifying the first excipient, wherein modifying the first excipient comprises modification to two or more properties of the first excipient selected from the group consisting of polymer chain spacing, hydrophilicity, molecular charge, cyclic chain density, aliphatic chain length, functional group density, molecular weight, glass transition temperature, and crystallinity percentage;
selecting a second therapeutic agent;
selecting a second excipient;
modifying the second excipient, wherein modifying the second excipient comprises modification to at least one property of the excipient selected from the group consisting of polymer chain spacing, hydrophilicity, molecular charge, cyclic chain density, aliphatic chain length, functional group density, molecular weight, glass transition temperature, and crystallinity percentage;
blending the first therapeutic agent and the first excipient and the second therapeutic agent and the second excipient to define a coating; and
applying the coating to the outer surface of the balloon, wherein the first therapeutic agent and the first excipient have a weight ratio of about 20;
1 to about 1;
20, and further wherein the coating enables transfer of a therapeutically effective amount of the therapeutic agent to a body lumen within less than one hour.
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Abstract
A drug delivery balloon is provided, the a balloon having an outer surface, and a tunable coating disposed on at least a length of the balloon surface. The tunable coating includes a first therapeutic agent and a first excipient, and can include a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable.
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Citations
41 Claims
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1. A method of coating an outer surface of a balloon of a balloon catheter, the method comprising:
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selecting a first therapeutic agent; selecting a first excipient; modifying the first excipient, wherein modifying the first excipient comprises modification to two or more properties of the first excipient selected from the group consisting of polymer chain spacing, hydrophilicity, molecular charge, cyclic chain density, aliphatic chain length, functional group density, molecular weight, glass transition temperature, and crystallinity percentage; selecting a second therapeutic agent; selecting a second excipient; modifying the second excipient, wherein modifying the second excipient comprises modification to at least one property of the excipient selected from the group consisting of polymer chain spacing, hydrophilicity, molecular charge, cyclic chain density, aliphatic chain length, functional group density, molecular weight, glass transition temperature, and crystallinity percentage; blending the first therapeutic agent and the first excipient and the second therapeutic agent and the second excipient to define a coating; and applying the coating to the outer surface of the balloon, wherein the first therapeutic agent and the first excipient have a weight ratio of about 20;
1 to about 1;
20, and further wherein the coating enables transfer of a therapeutically effective amount of the therapeutic agent to a body lumen within less than one hour. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 40, 41)
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22. A method of tuning the solubility of a coating for a medical device balloon of a balloon catheter, the method comprising:
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selecting a first therapeutic agent; selecting a first excipient; modifying the first excipient, wherein modifying the first excipient comprises modification to two or more properties of the excipient selected from the group consisting of polymer chain spacing, hydrophilicity, molecular charge, cyclic chain density, aliphatic chain length, functional group density, molecular weight, glass transition temperature, and crystallinity percentage; blending the first agent and the first excipient to define a first coating, the first coating having a first dissolution rate; selecting a second therapeutic agent; selecting a second excipient; modifying the second excipient, wherein modifying the second excipient comprises modification to at least one property of the excipient selected from the group consisting of polymer chain spacing, hydrophilicity, molecular charge, cyclic chain density, aliphatic chain length, functional group density, molecular weight, glass transition temperature, and crystallinity percentage; blending the second therapeutic agent and second excipient to define a second coating, the second coating having a second dissolution rate;
wherein the first and second dissolution rates are different; andapplying the first and second coatings to at least one length of an outer surface of the balloon, the different dissolution rates defining a tunable solubility. - View Dependent Claims (23, 24, 25, 26, 38, 39)
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Specification