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Modified exendins and exendin agonists

  • US 8,951,962 B2
  • Filed: 05/17/2013
  • Issued: 02/10/2015
  • Est. Priority Date: 04/30/1999
  • Status: Expired due to Fees
First Claim
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1. A compound comprising exendin-4, or agonist analog of exendin-4, linked to a polyamino acid through the C-terminal amino acid of the exendin-4 or agonist analog of exendin-4, wherein the agonist analog of exendin-4 comprises one or more naturally occurring amino acids deleted or replaced with another amino acid or amino acids and said polyamino acid is selected from the group consisting of poly(L-lysine), poly-glutamic acid, and poly-aspartic acid.

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