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Hydrogel tissue adhesive having reduced degradation time

  • US 8,951,989 B2
  • Filed: 04/09/2010
  • Issued: 02/10/2015
  • Est. Priority Date: 04/09/2009
  • Status: Expired due to Fees
First Claim
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1. A kit for forming a hydrogel comprising:

  • a) at least one oxidized polysaccharide containing aldehyde groups, said oxidized polysaccharide having a weight-average molecular weight of about 1,000 to about 1,000,000 Daltons and having an equivalent weight per aldehyde group of about 65 to about 1500 Daltons;

    b) at least one water-dispersible, multi-arm polyether amine wherein at least three of the arms are terminated by at least one primary amine group, said multi-arm polyether amine having a number-average molecular weight of about 450 to about 200,000 Daltons; and

    c) at least one oligomer of the formula;


    R1-(PS)-R2wherein;

    (i) PS is a linear polymeric segment comprising ethylene oxide monomers or a combination of ethylene oxide and propylene oxide monomers, wherein said ethylene oxide monomers comprise at least 50 weight percent of said polymeric segment;

    (ii) R1 is at least one nucleophilic group capable of reacting with aldehyde groups to form at least one reversible covalent bond;

    (iii) R2 is at least one functional group which is not capable of reacting with an aldehyde, a primary amine, a secondary amine, or R1 to form a covalent bond, such that said oligomer does not induce gelation when mixed in an aqueous medium with either (a) alone or (b) alone;

    (iv) said oligomer has a weight-average molecular weight of about 200 to about 10,000 Daltons; and

    (v) said oligomer is water soluble; and

    wherein said hydrogel has a decreased degradation time compared to a hydrogel formed under the same conditions in the absence of said oligomer.

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