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Method for imaging and differential analysis of cells

  • US 8,953,866 B2
  • Filed: 04/30/2012
  • Issued: 02/10/2015
  • Est. Priority Date: 03/16/2004
  • Status: Active Grant
First Claim
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1. A method for identifying a specific cell as being of a known cell type, wherein the known cell type relates to the viability of the cell, comprising:

  • staining a nucleus of the specific cell with a fluorescence stain;

    directing incident light at the specific cell to obtain a nuclear image and a brightfield image of the specific cell with a light detector; and

    determining the known cell type to which the specific cell corresponds, based on morphologic features of the specific cell that are derived from the nuclear image and the brightfield image, wherein the morphologic features include at least one morphologic feature selected from the group consisting of a size of the specific cell, a size of a nucleus in the specific cell, and a brightfield image contrast of the specific cell.

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