Firing patterns for deep brain transcranial magnetic stimulation
First Claim
1. A Transcranial Magnetic Stimulation (TMS) method for stimulating a primary brain target of neuronal tissue deep within a subject'"'"'s brain by firing a plurality of electromagnets located at different locations around the subject'"'"'s head at different secondary targets, the method comprising:
- firing a first electromagnet with a first duration, rate and power to emit an electromagnetic pulse and stimulate a first secondary brain target connected to a target deep region of the subject'"'"'s brain along a first pathway through the subject'"'"'s brain;
firing a second electromagnet following a waiting period after the firing of the first electromagnet has finished, wherein the second electromagnet is fired with a second duration, rate and power to emit an electromagnetic pulse and stimulate a second secondary brain target connected to the target deep region of the subject'"'"'s brain along a second pathway through the subject'"'"'s brain;
wherein the first duration, rate and power are different from the second duration, rate and power; and
triggering stimulation in the target deep region of the subject'"'"'s brain located in an intersection of the first and second pathways through the first and second pathways.
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Abstract
Methods, devices and systems for Transcranial Magnetic Stimulation (TMS) are provided for synchronous, asynchronous, or independent triggering the firing multiple of electromagnets from either a single power source or multiple energy sources. These methods are particularly useful for stimulation of deep (e.g., sub-cortical) brain regions, or for stimulation of multiple brain regions, since controlled magnetic pulses reaching the deep target location may combine to form a patterned pulse train that activates the desired volume of target tissue. Furthermore, the methods, devices and systems described herein may be used to control the rate of firing of action potentials in one or more brain regions, such as slow or fast rate rTMS. For example, described herein are multiple electromagnetic stimulation sources, each of which are activated independently to create a cumulative effect at the intersections of the electromagnetic stimulation trajectories, typically by means of a computerized calculation.
138 Citations
14 Claims
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1. A Transcranial Magnetic Stimulation (TMS) method for stimulating a primary brain target of neuronal tissue deep within a subject'"'"'s brain by firing a plurality of electromagnets located at different locations around the subject'"'"'s head at different secondary targets, the method comprising:
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firing a first electromagnet with a first duration, rate and power to emit an electromagnetic pulse and stimulate a first secondary brain target connected to a target deep region of the subject'"'"'s brain along a first pathway through the subject'"'"'s brain; firing a second electromagnet following a waiting period after the firing of the first electromagnet has finished, wherein the second electromagnet is fired with a second duration, rate and power to emit an electromagnetic pulse and stimulate a second secondary brain target connected to the target deep region of the subject'"'"'s brain along a second pathway through the subject'"'"'s brain; wherein the first duration, rate and power are different from the second duration, rate and power; and triggering stimulation in the target deep region of the subject'"'"'s brain located in an intersection of the first and second pathways through the first and second pathways. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A Transcranial Magnetic Stimulation (TMS) method for stimulating a primary brain target of neuronal tissue deep within a subject'"'"'s brain by firing a plurality of electromagnets located at different locations around the subject'"'"'s head at different secondary targets, the method comprising:
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firing a first electromagnet with a first stimulation pattern so that a plurality of electromagnetic pulses are emitted and stimulate a first secondary brain target connected to a target deep region of the subject'"'"'s brain along a first pathway; asynchronously firing a second electromagnet following a waiting period after the firing of the first electromagnet has finished, wherein the second electromagnet is fired with a second stimulation pattern so that a plurality of electromagnetic pulses are emitted and stimulate a second secondary brain target connected to the target deep region of the subject'"'"'s brain along a second pathway; triggering a pattern of stimulation at the target deep region of the subject'"'"'s brain located in an intersection of the first and second pathways through the first and second pathways.
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14. A Transcranial Magnetic Stimulation (TMS) method for stimulating a primary brain target of neuronal tissue deep within a subject'"'"'s brain by firing a plurality of electromagnets located at different locations around the subject'"'"'s head at different secondary targets, the method comprising:
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firing a first electromagnet with a first duration, rate and power to emit an electromagnetic pulse and stimulate a first secondary brain target connected to a deep target region along a first pathway through the subject'"'"'s brain; firing a second electromagnet with a second duration, rate and power to emit an electromagnetic pulse and stimulate a second secondary brain target connected to the deep brain target region along a second pathway through the subject'"'"'s brain; wherein the first duration, rate and power are different from the second duration, rate and power; and triggering stimulation in the target deep region of the subject'"'"'s brain located in an intersection of the first and second pathways through the first and second pathways.
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Specification