Amphiphilic compounds and self-assembling compositions made therefrom

• US 8,956,603 B2
• Filed: 02/22/2010
• Issued: 02/17/2015
• Est. Priority Date: 02/21/2009
• Status: Active Grant

• Current Assignee: Sofradim Production
• Original Assignee: Sofradim Production
• Inventors: Ladet, Sbastien, Gravagna, Philippe
• Primary Examiner(s): Pallay, Michael B
• Application Number:
  US13/202,376
• Publication Number:
  US 20120052042A1
• Time in Patent Office: 1,821 Days
• Field of Search: None
• US Class Current: 424/78.17
• CPC Class Codes: A61K 47/34 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers A61K47/10 takes precedence
• CPC Class Codes: C08L 5/00 Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00

Abstract

The present disclosure relates to amphiphilic compounds, self assembling compositions formed from the amphiphilic compounds and methods of making such compositions.

Claims

1. An amphiphilic compound comprising:

a hydrophilic portion and a hydrophobic portion, and

at least a first and second reactive member where the second reactive member is complementary to the first reactive member in that the first and second reactive members are able to interact with one another via a click chemistry reaction to form covalent bonds between each other, said first and second reactive members selected from alkyne groups and azides groups,

wherein one of said hydrophilic portion and said hydrophobic portion includes both the first and second reactive members.

2. The amphiphilic compound according to claim 1, wherein the first and second reactive members are located on the hydrophilic portion.

3. The amphiphilic compound according to claim 2, wherein the hydrophilic portion includes a plurality of first reactive members.

4. The amphiphilic compound according to claim 3, wherein the hydrophilic portion includes a plurality of second reactive members.

5. An amphiphilic compound according to claim 4, further comprising a terminal reactive member on the hydrophilic portion.

6. The amphiphilic compound of claim 1, wherein the first and second reactive members are located on the hydrophobic portion.

7. The amphiphilic compound according to claim 6, wherein the hydrophobic portion includes a plurality of first reactive members.

8. The amphiphilic compound according to claim 7, wherein the hydrophobic portion includes a plurality of second reactive members.

9. A composition comprising a hydrophilic solvent and a plurality of amphiphilic compounds according to claim 2.

10. A composition comprising a hydrophilic solvent;

optionally a catalyst;

at least a first amphiphilic compound; and

at least a second amphiphilic compound, said first and second amphiphilic compound being an amphiphilic compound according to claim 4.