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Bupivacaine formulation in a polyorthoester carrier

  • US 8,956,642 B2
  • Filed: 04/17/2009
  • Issued: 02/17/2015
  • Est. Priority Date: 04/18/2008
  • Status: Active Grant
First Claim
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1. An implantable drug depot useful for reducing, or treating pain in a patient in need of such treatment, the drug depot comprising a polyorthoester and bupivacaine, the drug depot adapted to be administered intraspinally in the patient to reduce, or treat pain, wherein the drug depot is capable of releasing bupivacaine for a period of at least 30 days after administration, wherein the bupivacaine has a particle size range of about 5 microns to 50 microns, comprises a surface for burst release of the bupivacaine, has a modulus of elasticity in the range of about 2×

  • 104 to about 5×

    105 dynes/cm2, and wherein the drug depot comprises mPEG.

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