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Retinal pigment epithelial cells differentiated from embryonic stem cells with nicotinamide and activin A

  • US 8,956,866 B2
  • Filed: 04/27/2008
  • Issued: 02/17/2015
  • Est. Priority Date: 04/18/2007
  • Status: Active Grant
First Claim
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1. A method for promoting directed differentiation of human pluripotent stem cells into retinal pigment epithelium (RPE) fate, the method comprising:

  • (a) culturing human pluripotent stem cells in a medium supplemented with nicotinamide (NA) to generate differentiating cells; and

    subsequently(b) culturing said differentiating cells in a medium supplemented with activin A under conditions which induce said differentiating cells to differentiate into RPE cells.

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