Methods for preventing or treating mitochondrial permeability transition
First Claim
1. A method for increasing cardiac contractility in a subject in need thereof, comprising administering to the subject an effective amount of the peptide D-Arg-2′
- 6′
-Dmt-Lys-Phe-NH2, wherein cardiac contractility is reduced due to ischemia-reperfusion injury, coronary artery disease, atherosclerosis, thrombolytic blockage, glucose deprivation, or hypoxia.
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Accused Products
Abstract
The invention provides a method of reducing or preventing mitochondrial permeability transitioning. The method comprises administering an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3pm is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2 a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1.
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Citations
12 Claims
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1. A method for increasing cardiac contractility in a subject in need thereof, comprising administering to the subject an effective amount of the peptide D-Arg-2′
- 6′
-Dmt-Lys-Phe-NH2, wherein cardiac contractility is reduced due to ischemia-reperfusion injury, coronary artery disease, atherosclerosis, thrombolytic blockage, glucose deprivation, or hypoxia. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
- 6′
Specification