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Treatment of reprogramming factor related diseases by inhibition of natural antisense transcript to a reprogramming factor

  • US 8,957,037 B2
  • Filed: 05/18/2010
  • Issued: 02/17/2015
  • Est. Priority Date: 05/18/2009
  • Status: Active Grant
First Claim
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1. A method of upregulating a function of or the expression of a Reprogramming factor polynucleotide selected from SEQ ID NOS:

  • 1,2 or 3 in mammalian cells or tissues in vivo or in vitro comprising;

    contacting said cells or tissues with at least one single stranded antisense oligonucleotide 14 to 28 nucleotides in length wherein said at least one oligonucleotide is specific for a natural antisense polynucleotide of said Reprogramming thetor polynucleotide and has at least 90% sequence identity to a reverse complement of said natural antisense polynucleotide comprising 10 to 30 consecutive nucleotides within nucleotides 1 to 993 of SEQ ID NO;

    4, 1 to 493 of SEQ ID NO;

    5, and 1 to 418 of SEQ ID NO;

    6;

    thereby upregulating a function of and/or the expression of the Reprogramming factor polynucleotide in mammalian cells or tissues in vivo or in vitro.

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