Systems and methods for determining physiological characteristics of a patient using pulse oximetry

• US 8,958,859 B2
• Filed: 05/14/2012
• Issued: 02/17/2015
• Est. Priority Date: 05/17/2011
• Status: Active Grant

• Current Assignee: LionsGate Technologies, Inc.
• Original Assignee: LionsGate Technologies, Inc.
• Inventors: Petersen, Christian Leth, Ansermino, John Mark, Dumont, Guy
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US14/118,177
• Publication Number:
  US 20140073887A1
• Time in Patent Office: 1,009 Days
• Field of Search: 600/300, 600/301, 600/310, 600/322, 600/323
• US Class Current: 600/323
• CPC Class Codes: A61B 2560/045 with a separable interface unit, e.g. for communication
• CPC Class Codes: A61B 2562/227 Sensors with electrical connectors
• CPC Class Codes: A61B 5/0004 characterised by the type of physiological signal transmitted
• CPC Class Codes: A61B 5/0015 characterised by features of the telemetry system
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/02433 for infrared radiation
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/6826 Finger
• CPC Class Codes: A61B 5/6898 Portable consumer electronic devices, e.g. music players, telephones, tablet computers
• CPC Class Codes: A61B 5/7228 Signal modulation applied to the input signal sent to patient or subject; demodulation to recover the physiological signal modulation H03C
• CPC Class Codes: A61B 5/7278 Artificial waveform generation or derivation, e.g. synthesising signals from measured signals A61B5/327 takes precedence
• CPC Class Codes: A61B 5/746 Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms alarms per se G08B

Abstract

Methods, systems and related apparatus are provided to enable an electronic device to operate an external sensor comprising one or more emitters for emitting electromagnetic radiation of two different wavelengths and a detector for generating a response signal based on received electromagnetic radiation of the two different wavelengths connectable to an audio interface by applying a harmonic driving signal to a first contact and a second contact of the audio interface for driving the emitters of the external sensor, receiving the response signal at a third contact of the audio interface, demodulating and demultiplexing the response signal into a first wavelength response signal and a second wavelength response signal, analyzing the first and second wavelength response signals to determine one or more vital signs, and outputting the determined one or more vital signs.

Claims

1. A method for controlling an electronic device to operate an external sensor to obtain one or more vital signs, the electronic device having an audio interface comprising a plurality of contacts, the external sensor connectable to the audio interface and comprising one or more emitters for emitting electromagnetic radiation of two different wavelengths and a detector for generating a response signal based on received electromagnetic radiation of the two different wavelengths, the method comprising:

applying a harmonic driving signal to a first contact and a second contact of the audio interface for driving the one or more emitters of the external sensor, the harmonic driving signal comprising a first sinusoidal driving signal applied to the first contact of the audio interface and a second sinusoidal driving signal to the second contact of the audio interface, the first and second sinusoidal signals being substantially 180 degrees out of phase;

receiving the response signal at a third contact of the audio interface;

demodulating and demultiplexing the response signal into a first wavelength response signal and a second wavelength response signal;

analyzing the first and second wavelength response signals to determine one or more vital signs; and

outputting the determined one or more vital signs.

2. The method of claim 1 wherein:

applying the harmonic driving signal comprises applying the first sinusoidal driving signal to a first speaker contact of the audio interface and applying the second sinusoidal driving signal to a second speaker contact of the audio interface; and

receiving the response signal comprises receiving the response signal at a microphone contact of the audio interface.

3. The method of claim 1 wherein demodulating and demultiplexing the response signal comprises quadrature demodulating the response signal using a first pair of sinusoidal signals having the first frequency and a phase offset of 90 degrees to obtain a first demodulation signal, and quadrature demodulating the response signal using a second pair of sinusoidal signals having a second frequency equal to twice the first frequency and a phase offset of 90 degrees to obtain a second demodulation signal.

4. The method of claim 3 comprising determining the first wavelength response signal based on a first linear combination of the first and second demodulation signals, and determining the second wavelength response signal based on a second linear combination of the first and second demodulation signals.

5. The method of claim 1 wherein the one or more emitters comprise a pair of emitters connectable in parallel with opposing polarities across the first and second contacts, each emitter of the pair of emitters having an activation voltage, and wherein each of the first and second sinusoidal driving signals comprises a base harmonic signal with a base amplitude of less than the activation voltages of the emitters and periodic positive polarity triggering peaks and negative polarity triggering peaks with amplitudes greater than the activation voltages.

6. The method of claim 5 comprising providing the positive polarity triggering peaks and negative polarity triggering peaks at a frequency substantially the same as a sampling frequency of the response signal.

7. The method of claim 6 comprising providing the positive polarity triggering peaks and negative polarity triggering peaks in alternating fashion, wherein a first time period from one of the positive polarity triggering peaks to a subsequent one of the negative polarity triggering peaks is different from a second time period from one of the negative polarity triggering peaks to a subsequent one of the positive polarity triggering peaks.

8. The method of claim 7 wherein demodulating and demultiplexing the response signal comprises detecting peaks separated by the first time period and the second time period to identify the first wavelength response signal and the second wavelength response signal.

9. The method of claim 5 wherein the pair of emitters comprise a red LED and an infrared LED, and wherein the one of the positive polarity triggering peaks and negative polarity triggering peaks for triggering the infrared LED have a lower amplitude than the other one of the positive polarity triggering peaks and negative polarity triggering peaks for triggering the red LED.

10. The method of claim 5 comprising dynamically adjusting amplitudes of the positive polarity triggering peaks and the negative polarity triggering peaks to maintain DC levels of the first and second wavelength response signals within a predetermined range of a control setpoint.

11. The method of claim 1 wherein the audio interface comprises a TRRS audio interface.

12. A program product comprising a machine readable memory storing executable instructions thereon that when executed by a processor of an electronic device having an audio interface cause the electronic device to perform the method of claim 1.

13. A system for controlling an electronic device to operate an external sensor to obtain one or more vital signs, the electronic device having an audio interface comprising a plurality of contacts, the external sensor connectable to the audio interface and comprising one or more emitters for emitting electromagnetic radiation of two different wavelengths and a detector for generating a response signal based on received electromagnetic radiation of the two different wavelengths, the system comprising:

a driving signal generator configured to apply a harmonic driving signal to a first contact and a second contact of the audio interface for driving the one or more emitters of the external sensor, the harmonic driving signal comprising a first sinusoidal driving signal applied to the first contact of the audio interface and a second sinusoidal driving signal to the second contact of the audio interface, the first and second sinusoidal signals being substantially 180 degrees out of phase;

a response signal demodulator and demultiplexer configured to receive the response signal from a third contact of the audio interface and demodulate and demultiplex the response signal into a first wavelength response signal and a second wavelength response signal;

a response signal analyzer configured to analyze the first and second wavelength response signals to determine one or more vital signs; and

an output configured to output the determined one or more vital signs.

14. The system of claim 13 wherein:

the driving signal generator is configured to apply the first sinusoidal driving signal to a first speaker contact of the audio interface and apply the second sinusoidal driving signal to a second speaker contact of the audio interface; and

the response signal demodulator and demultiplexer is configured to receive the response signal at a microphone contact of the audio interface.

15. The system of claim 13 wherein the response signal demodulator and demultiplexer is configured to quadrature demodulate the response signal using a first pair of sinusoidal signals having the first frequency and a phase offset of 90 degrees to obtain a first demodulation signal, and quadrature demodulate the response signal using a second pair of sinusoidal signals having a second frequency equal to twice the first frequency and a phase offset of 90 degrees to obtain a second demodulation signal.

16. The system of claim 15 wherein the response signal demodulator and demultiplexer is configured to determine the first wavelength response signal based on a first linear combination of the first and second demodulation signals, and determine the second wavelength response signal based on a second linear combination of the first and second demodulation signals.

17. The system of claim 13 wherein the one or more emitters comprise a pair of emitters connectable in parallel with opposing polarities across the first and second contacts, each emitter of the pair of emitters having an activation voltage, and wherein the driving signal generator is configured to apply, for each of the first and second sinusoidal driving signals, a base harmonic signal with a base amplitude of less than the activation voltages of the emitters and periodic positive polarity triggering peaks and negative polarity triggering peaks with amplitudes greater than the activation voltages.

18. The system of claim 17 wherein the driving signal generator is configured to provide the positive polarity triggering peaks and negative polarity triggering peaks at a frequency substantially the same as a sampling frequency of the response signal.

19. The system of claim 18 wherein the driving signal generator is configured to provide the positive polarity triggering peaks and negative polarity triggering peaks in alternating fashion, wherein a first time period from one of the positive polarity triggering peaks to a subsequent one of the negative polarity triggering peaks is different from a second time period from one of the negative polarity triggering peaks to a subsequent one of the positive polarity triggering peaks.

20. The system of claim 19 wherein the response signal demodulator and demultiplexer is configured to detect peaks separated by the first time period and the second time period to identify the first wavelength response signal and the second wavelength response signal.

21. The system of claim 17 wherein the pair of emitters comprise a red LED and an infrared LED, and wherein the one of the positive polarity triggering peaks and negative polarity triggering peaks for triggering the infrared LED have a lower amplitude than the other one of the positive polarity triggering peaks and negative polarity triggering peaks for triggering the red LED.

22. The system of claim 17 wherein the driving signal generator is configured to dynamically adjust amplitudes of the positive polarity triggering peaks and the negative polarity triggering peaks to maintain DC levels of the first and second wavelength response signals within a predetermined range of a control setpoint.

23. The system of claim 13 wherein the audio interface comprises a TRRS audio interface.