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Neuroprotective electrical stimulation

  • US 8,958,881 B2
  • Filed: 03/25/2013
  • Issued: 02/17/2015
  • Est. Priority Date: 08/19/2005
  • Status: Active Grant
First Claim
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1. Apparatus for treating a subject, comprising:

  • one or more electrodes, configured to be applied to a site of the subject selected from the group consisting of;

    a sphenopalatine ganglion (SPG), a greater palatine nerve, a lesser palatine nerve, a sphenopalatine nerve, a communicating branch between a maxillary nerve and an SPG, an otic ganglion, an afferent fiber going into the otic ganglion, an efferent fiber going out of the otic ganglion, an infraorbital nerve, a vidian nerve, a greater superficial petrosal nerve, and a lesser deep petrosal nerve; and

    a control unit, configured to;

    drive the one or more electrodes to apply electrical stimulation to the site, andconfigure the stimulation to excite nervous tissue of the site at a strength that (a) is sufficient to induce at least one neuroprotective occurrence selected from the group consisting of;

    an increase in cerebral blood flow (CBF) of the subject, and a release of one or more neuroprotective substances, and (b) is insufficient to induce a significant increase in permeability of a blood-brain barrier (BBB) of the subject.

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