Graphical user interface for analysis and comparison of location-specific multiparameter data sets

• US 8,959,448 B2
• Filed: 04/16/2008
• Issued: 02/17/2015
• Est. Priority Date: 04/17/2007
• Status: Active Grant

• Current Assignee: Cytek Biosciences Inc
• Original Assignee: EMD Millipore Corporation (Merck & Co., Inc.)
• Inventors: Lefebvre, Ray, Kilcoin, Neil, King, David Andrew, Cappione, Amedeo Joseph III, Dixon, George J.
• Primary Examiner(s): Abdul-Ali, Omar
• Assistant Examiner(s): KEATON, SHERROD L
• Application Number:
  US12/104,234
• Publication Number:
  US 20080263468A1
• Time in Patent Office: 2,498 Days
• Field of Search: 715/810, 715/771, 715/764, 435/6.16, 435/6.17
• US Class Current: 715/771
• CPC Class Codes: G01N 2015/1402 Data analysis by thresholding or gating operations performed on the acquired signals or stored data
• CPC Class Codes: G01N 2015/1477 Multiparameters
• CPC Class Codes: G01N 2035/0091 GUI [graphical user interfaces]
• CPC Class Codes: G01N 35/00722 Communications; Identification
• CPC Class Codes: G06F 3/04817 using icons graphical or visual programming using iconic symbols G06F8/34
• CPC Class Codes: G16B 45/00 ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks

Abstract

A graphical user interface on a computer provides for the analysis of location specific data and the presentation of analysis results for visual comparison by a user. Results of the analysis are visually presented as icons subdivided into regions and arranged in such a way that the user is able to associate each icon with a data location. A visual presentation of results in the icons and regions allows a user to visually compare the analysis results in two or more data sets according to location. The graphical user interface further provides for the definition and adjustment of an analysis through the interaction of a user with a graphical representation of the analysis. In some cases, the visual presentation of results tracks the analysis adjustments so the user can visually observe the effects that the adjustments have on the results. A method of interacting with the interface to define an analysis and represent results and a method of presenting two or more data sets using the interface are described. The interface can be used to analyze and visually compare the results of location specific data from a number of sources and is illustrated in a flow cytometry application.

Claims

1. A graphical user interface embodied in a computer system including a display providing a visual representation of analyses of data sets resulting from cytometric interrogation of particle containing samples having a spatial arrangement, where the visual representation enables identification of relationships among the data sets, the interface comprising:

a spatial arrangement of icons on a display of a computer system similar to the spatial arrangement of the particle containing samples such that each of the icons is visually associated with two or more samples on two or more sample plates; and

at least one of the icons is divided into at least a first region and a second region, the first region of the icon displaying information regarding an analysis of a data set resulting from cytometric interrogation of a first particle containing sample on a first sample plate visually associated with the icon, and the second region of the icon displaying information regarding an analysis of a data set resulting from cytometric interrogation of a second particle containing sample on a second sample plate visually associated with the icon.

2. The graphical user interface of claim 1 wherein all of the icons are divided into regions, with each region representing an analysis of a data set including data from the sample visually associated with the icon.

3. The graphical user interface of claim 1 wherein the spatial arrangements of samples and icons are the same.

4. The graphical user interface of claim 1 wherein the samples are particle-containing biological samples.

5. The graphical user interface of claim 1 wherein the samples are interrogated using one of a flow cytometer and a scanning cytometer.

6. The graphical user interface of claim 1 wherein the visual representation of the information is a variation of one of color and visual tone.

7. The graphical user interface of claim 6 in which a hatched pattern is superimposed over the visual representation.

8. The graphical user interface of claim 6 in which the visual representation is logarithmically related to the information.

9. The graphical user interface of claim 1 wherein the icons are shaped to appear visually to have substantially the same shape as the samples.

13. The graphical user interface of claim 1 wherein the at least one of the icons is further divided into at least a third region displaying information regarding a further analysis of the data set resulting from cytometric interrogation of the first particle containing sample on the first sample plate visually associated with the icon, or displaying information regarding a further analysis of the data set resulting from cytometric interrogation of the second particle containing sample on the second sample plate visually associated with the icon.

10. A method of interacting with a graphical interface of a computer displaying two or more data sets, the method comprising the steps of:

providing a graphical interface including a spatial arrangement of icons that is similar to a spatial arrangement of particle containing samples such that each of the icons is visually associated with at least one of the samples, each of the icon is divided into at least a first region and a second region, the first regions of the icons displaying information regarding a first analysis of data sets resulting from cytometric interrogation of the particle containing samples visually associated with the icons, and the second regions of the icons displaying cytometric information regarding a second analysis of the data sets resulting from interrogation of the particle containing samples visually associated with the icons;

defining at least one cytometric analysis;

specifying units of measurement for the cytometric analysis;

applying the cytometric analysis to a data set to generate results and representing the results in a region of the icons.

11. The method of claim 10 wherein the samples are particle-containing biological samples.

12. The method of claim 10 wherein the samples are interrogated using a flow cytometer or scanning cytometer.