Charged particle cancer therapy patient positioning method and apparatus

• US 8,963,112 B1
• Filed: 10/07/2013
• Issued: 02/24/2015
• Est. Priority Date: 05/25/2011
• Status: Active Grant

• Current Assignee: Andrey Vladimirovich Balakin, Pavel Vladimirovich Balakin
• Original Assignee: Vladimir Balakin
• Inventors: Balakin, Vladimir
• Primary Examiner(s): Wells, Nikita
• Application Number:
  US14/047,807
• Time in Patent Office: 505 Days
• Field of Search: 250/505.1, 250/492.1, 250/492.3, 250/396.R, 315/503, 313/359.1
• US Class Current: 250/505.1
• CPC Class Codes: A61N 2005/1061 using an x-ray imaging system having a separate imaging source
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 5/1037 taking into account the movement of the target, e.g. 4D-image based planning
• CPC Class Codes: A61N 5/1049 for verifying the position of the patient with respect to the radiation beam
• CPC Class Codes: A61N 5/1067 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/107 in real time, i.e. during treatment

Abstract

The invention comprises a patient positioning and/or repositioning system, such as a laying, semi-vertical, or seated patient positioning, alignment, and/or control method and apparatus used in conjunction with multi-axis charged particle radiation therapy. Patient positioning constraints optionally include one or more of: a seat support, a back support, a head support, an arm support, a knee support, and a foot support. One or more of the positioning constraints are preferably movable and/or under computer control for rapid positioning, repositioning, and/or immobilization of the patient. The system optionally uses an X-ray beam that lies in substantially the same path as a proton beam path of a particle beam cancer therapy system. The generated image is usable for: fine tuning body alignment relative to the proton beam path, to control the charged particle beam path to accurately and precisely target the tumor, and/or in system verification and validation.

Claims

1. An apparatus for positioning a tumor of a patient for treatment with positively charged particles, comprising:

a charged particle irradiation system comprising a charged particle beam path;

a patient positioning system configured to place the patient in said charged particle beam path;

an emission foil positioned in said charged particle beam path; and

a coating on said emission foil, said coating comprising a layer yielding a localized photometric signal when struck by the positively charged particles, said localized photometric signal used to verify both a horizontal position of the positively charged particles and a vertical position of the positively charged particles in said charged particle beam path relative to the patient positioning system.

2. The apparatus of claim 1, wherein the positively charged particles travel along said charged particle beam path to the tumor of the patient.

3. The apparatus of claim 1, said coating comprising at least one of:

a phosphor; and

a luminescent material.

4. The apparatus of claim 3, said patient positioning system comprising a semi-upright patient support surface, said charged particle beam path passing within about six inches of said semi-upright patient support surface.

5. The apparatus of claim 1, said charged particle therapy system further comprising:

a synchrotron in the charged particle beam path; and

an extraction foil in the charged particle beam path, said extraction foil used in control of;

beam energy; and

beam intensity.

6. The apparatus of claim 1, wherein said patient positioning system further comprises:

a rotatable platform, wherein said charged particle beam path passes above a portion of said rotatable platform, wherein said rotatable platform comprises;

a lower support structure, said lower support structure holding a portion of said patient positioning system;

an upper support structure, said upper support structure configured to co-rotate with said lower support structure, said upper support structure holding in view of the patient during rotation of the patient;

a camera; and

a video screen.

7. The apparatus of claim 6, wherein said patient positioning system provides respiration instructions on said video screen in view of the patient while the patient is rotating through at least one hundred eighty degrees.

8. The apparatus of claim 1, said charged particle irradiation system further comprising:

a negative ion source, said negative ion source configured to produce negative ions;

an ion beam focusing lens configured to focus the negative ions; and

a converting foil, said converting foil configured to convert the negative ions into the positively charged particles.

9. The apparatus of claim 1, said charged particle irradiation system further comprising a synchrotron, said synchrotron comprising:

a center;

straight sections; and

turning sections,

wherein said charged particle beam path runs;

about said center;

through said straight sections; and

through said turning sections,

wherein each of said turning sections comprises a plurality of bending magnets,

wherein said circulation beam path comprises a length of less than sixty meters, and

wherein a number of said straight sections equals a number of said turning sections.

10. The apparatus of claim 9, wherein said turning sections each comprise at least four bending magnets, said four bending magnets comprising a total of at least eight edge focusing surfaces, wherein geometry of said edge focusing surfaces focuses the charged particles in said charged particle beam path during use.

11. The apparatus of claim 1, said charged particle irradiation system further comprising a synchrotron, said synchrotron having a center, said apparatus comprising:

an extraction material;

at least a one kilovolt direct current field applied across a pair of extraction blades; and

a deflector,

wherein the charged particles pass through said extraction material resulting in a reduced energy charged particle beam,

wherein the reduced energy charged particle beam passes between said pair of extraction blades, and

wherein the direct current field redirects the reduced energy charged particle beam through said deflector,

wherein said deflector yields extracted charged particles.

12. The apparatus of claim 1, further comprising:

an X-ray generation source located within forty millimeters of the charged particle beam path, wherein said X-ray source maintains a single static position;

(1) during use of said X-ray source and (2) during tumor treatment with the charged particles,

wherein X-rays emitted from said X-ray source run substantially in parallel with the charged particle beam path.

13. The apparatus of claim 1, wherein said charged particle irradiation system further comprises:

horizontal position control of the charged particles;

vertical position control of the charged particles; and

an X-ray input signal, wherein said X-ray input signal comprises a signal generated by an X-ray source proximate said charged particle beam path,

wherein said X-ray input signal is used in;

setting position of said horizontal position and setting position of said vertical position.

14. The apparatus of claim 1, wherein said charged particle irradiation system further comprises:

a synchrotron comprising multi-axis control, said multi-axis control comprising control of;

an energy; and

an intensity,

wherein said control of said energy and said control of said intensity occurs during extraction.

15. The apparatus of claim 14, further comprising separate control of said energy and said intensity during an extraction phase of said synchrotron.

16. A method for positioning a tumor of a patient for treatment with positively charged particles, comprising:

positioning the patient relative to a charged particle beam path with a patient positioning system;

transmitting the positively charged particles through a foil, said foil comprising a layer yielding a localized photometric signal when struck by the positively charged particles;

verifying both a horizontal position of the positively charged particles and a vertical position of the positively charged particles relative to the patient positioning system using the localized photometric signal.

17. The method of claim 16, said photometric signal comprising photons emitted from said foil as a result of the positively charged particles striking said foil.

18. The method of claim 17, further comprising the steps of:

after said step of positioning, collected multi-field images of the tumor in the patient;

developing a tumor irradiation plan;

repositioning the tumor using said patient positioning system; and

repeating said step of irradiating in at least four rotation positions.

19. The method of claim 18, further comprising the step of:

after said step of repositioning, verifying position of the tumor.

20. The method of claim 17, further comprising the steps of:

varying intensity of the charged particles dependent upon efficiency of delivery of energy of the charged particles within the tumor versus delivery of energy of the charged particles to healthy tissue of the patient.

21. The method of claim 17, further comprising the steps of:

controlling an energy of the charged particle using an accelerator in said charged particle system, said accelerator comprising;

a set of at least ten coils;

a set of at least ten wire loops; and

a set of at least ten microcircuits, each of said microcircuits integrated to one of said loops, wherein each of said loops completes at least one turn about at least one of said coils; and

using a radio-frequency synthesizer, sending a low voltage signal to each of said microcircuits, each of said microcircuits amplifying said low voltage signal yielding an acceleration voltage.