System and method of predicting future fractures
First Claim
1. A method for predicting fracture risk using electronic image data of a part of a skeleton of a target in a computer system, the method comprising:
- analyzing at least one bone structure parameter corresponding to at least a portion of the target in one or more regions of interest (ROIs);
generating a parameter map from a measurement for the at least one bone structure parameter to predict a fracture line;
analyzing the at least one bone structure parameter along the predicted fracture line to predict a fracture load at which a fracture will occur; and
predicting a fracture risk by calculating a ratio between the fracture load and a peak impact force on the part of the skeleton of the target using a body habitus of the target;
comparing the at least one bone structure parameter to a reference parameter to identify a likely location of the fracture; and
predicting the fracture load of the target with the target'"'"'s bone structure parameter and a correlation of the reference parameter.
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Accused Products
Abstract
Methods of predicting fracture risk of a patient include: obtaining an image of a bone of the patient; determining one or more bone structure parameters; predicting a fracture line with the bone structure parameter; predicting a fracture load at which a fracture will happen; estimating body habitus of the patient; calculating a peak impact force on the bone when the patient falls; and predicting a fracture risk by calculating the ratio between the peak impact force and the fracture load. Inventive methods also include determining the effect of a candidate agent on any subject'"'"'s risk of fracture.
206 Citations
23 Claims
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1. A method for predicting fracture risk using electronic image data of a part of a skeleton of a target in a computer system, the method comprising:
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analyzing at least one bone structure parameter corresponding to at least a portion of the target in one or more regions of interest (ROIs); generating a parameter map from a measurement for the at least one bone structure parameter to predict a fracture line; analyzing the at least one bone structure parameter along the predicted fracture line to predict a fracture load at which a fracture will occur; and predicting a fracture risk by calculating a ratio between the fracture load and a peak impact force on the part of the skeleton of the target using a body habitus of the target; comparing the at least one bone structure parameter to a reference parameter to identify a likely location of the fracture; and predicting the fracture load of the target with the target'"'"'s bone structure parameter and a correlation of the reference parameter. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A system for analyzing musculoskeletal-related data of a target using a computer, comprising:
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means for receiving an image of a part of a skeleton of the target; means for deriving at least one bone structure parameter from the image; means for calculating a possibility of a fracture of the target using the at least one bone structure parameter of the target; means for analyzing the target'"'"'s bone structure parameter in one or more regions of interest (ROIs) to predict a possible fracture line and calculate a fracture load of the target; means for estimating or measuring a body habitus of the target; and means for calculating a peak impact force on the skeleton part when the target falls; means for obtaining a fracture load of a skeleton part of a reference; means for correlating a bone structure parameter of the reference to the fracture load of the reference; means for predicting a fracture risk by calculating a ratio between the fracture load and the peak impact force on the part of the skeleton of the target using a body habitus of the target; and means for receiving the target'"'"'s bone structure parameter and the correlation of the reference'"'"'s bone structure parameter, and calculating the fracture load of the target. - View Dependent Claims (22, 23)
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Specification