Method and apparatus for treating cancer

• US 8,965,527 B2
• Filed: 03/11/2014
• Issued: 02/24/2015
• Est. Priority Date: 08/08/2011
• Status: Active Grant

• Current Assignee: Medamp Electronics LLC
• Original Assignee: Medamp Electronics LLC
• Inventors: Ruse, Richard B., Bohanan, Scott J., Crawford, E. David, Nabors, William L. Sr.
• Primary Examiner(s): Hupczey, Jr., Ronald
• Assistant Examiner(s): AVIGAN, ADAM JOSEPH
• Application Number:
  US14/203,633
• Publication Number:
  US 20140200574A1
• Time in Patent Office: 350 Days
• Field of Search: 607 98-102, 607/113, 606 28- 29, 606 39- 41, 606 49- 50
• US Class Current: 607/99
• CPC Class Codes: A61B 18/1477 Needle-like probes
• CPC Class Codes: A61B 2018/00005 Cooling or heating of the probe or tissue immediately surrounding the probe
• CPC Class Codes: A61B 2018/00107 Coatings on the energy applicator
• CPC Class Codes: A61B 2018/0016 Energy applicators arranged in a two- or three dimensional array
• CPC Class Codes: A61B 2018/00547 Prostate
• CPC Class Codes: A61B 2018/00791 Temperature
• CPC Class Codes: A61B 2018/1467 using more than two electrodes on a single probe
• CPC Class Codes: A61B 2090/3925 ultrasonic
• CPC Class Codes: A61B 5/015 By temperature mapping of body part

Abstract

A method and apparatus for treating masses, such as prostate or breast cancer, or any other soft tissue cancerous or benign mass, employs a unique, three-dimensional software-controlled electronic amplifier array using arbitrary waveforms that dynamically and proportionally steer electrical currents by using two or more current vector paths, sequentially or simultaneously, through a mass containing electrically-conductive ionic solutions so as to obtain 100% thermal beating or hyperthermia through the mass, and destroying it with a minimally-invasive treatment which requires no radiation or chemotherapy which could be harmful to the patient.

Claims

1. A method for treating a mass within a patient'"'"'s body, which comprises:

positioning three or more electrode shafts that define an area around a mass, each shaft having at least two electrode bands positioned along the shaft;

generating instructive signals from a processor that are DC arbitrary waveforms or AC arbitrary waveforms of a frequency of up to about 1 KHz; and

receiving the instructive signals from the processor in an amplifier array configured to receive such signals and to deliver signals to the electrode bands,

wherein the processor is configured to control the amplifier array in such a way as to proportionately vary the voltage amplitude of signals to the electrode bands to dynamically steer and focus ionic current vectors to create and steer a hot zone anywhere in three dimensions within the area between the electrode shafts, without moving the electrodes, to resistively heat the mass to ensure destruction of all malignant or benign cells.

2. The method of claim 1, wherein each electrode shaft has three electrode bands.

3. The method of claim 1, wherein the processor-controlled electronic amplifier array generates signals to dynamically and proportionally steer current vectors under software control using a computer.

4. The method of claim 3, wherein the processor manages the voltage, current, pulse-widths, arbitrary waveforms and thermal data and makes adjustments to the amplifier drive voltage amplitudes.

5. The method of claim 1 comprising the additional step of:

inserting two or more biopsy probes or needles into a patient'"'"'s organ to determine the extent of a mass.

6. The method of claim 5, wherein the biopsy probes or needles are removed before electrode shafts are inserted into the patient.

7. The method of claim 5, wherein biopsy probes or needles are capable of functioning as electrode shafts having two or more electrode bands.

8. The method of claim 1, wherein the processor contains pre-programmed protocols to permit a medically trained operator to select a particular protocol for treating a mass.

9. The method of claim 1, wherein each electrode shaft has two or more platinum bands or contact points as electrode bands.

10. The method of claim 1, wherein each electrode shaft has a distal tip with a dissolvable coating or substrate.

11. The method of claim 1, wherein each electrode shaft has one or more inflatable components that can be inflated to provide mechanical stability while surrounding a malignant or benign mass being treated.

12. The method of claim 1 for treating malignant or benign masses which occur in a breast, liver, lungs, brain, pancreas, uterus, prostate, or ovary or elsewhere within a patient'"'"'s body.

13. The method of claim 1, wherein each electrode shaft comprises a cooling system to dynamically cool the electrode bands during treatment.

14. The system of claim 1, wherein each electrode shaft has at least one thermal sensor to provide feedback to the processor.

15. The method of claim 14, wherein the processor samples and analyzes thermal data from the thermal sensors and manages the amplifier-delivered energy by adjusting voltage amplitudes and pulse-widths of waveforms delivered to the electrode bands.

16. The method of claim 1, wherein the materials and construction of the electrode shafts and electrode bands will be such that visual surface contrasts of the electrode shafts and the electrode bands can be differentiated by a medically trained operator using conventional ultrasound or other imaging equipment.

17. The method of claim 1, wherein all the ionic current vectors combine to generate controlled and focused hyperthermia.

18. The method of claim 1, wherein the ionic current vectors are steered to uniformly elevate areas of the mass to a temperature of from about 48°

C. to about 50°

C., until all malignant or benign cells within the mass are neutralized so that further abnormal cell growth cannot occur.

19. The method of claim 1, wherein three or more electrode shafts with electrode bands will be capable of being inserted into holes within a grid block while an ultrasound video is used simultaneously as a mechanical guide to surround the malignant or benign mass.

20. A method for treating a mass within a patient'"'"'s body, which comprises:

positioning three or more electrode shafts that define an area around a mass, each shaft having at least two electrode bands positioned along the shaft;

generating instructive signals from a processor that are DC arbitrary waveforms or AC arbitrary waveforms of a frequency of up to about 1 KHz; and

receiving instructive signals from the processor in an amplifier array configured to receive such signals and to deliver signals to the electrode bands,

wherein the processor is configured to control the amplifier array in such a way as to proportionately vary the voltage amplitude of signals to the electrode bands to dynamically steer and focus ionic current vectors to create and steer a hot zone anywhere in three dimensions within the area between the electrode shafts and around the perimeter of the mass using a fencing technique, without moving the electrodes, to destroy vasculature which feeds nutrients and blood supply to the mass by resistive heating.

21. The method of claim 20, wherein each electrode shaft has at least one thermal sensor to provide feedback to the processor.