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Method and system for determining the accuracy of DNA base identifications

  • US 8,965,711 B2
  • Filed: 02/06/2013
  • Issued: 02/24/2015
  • Est. Priority Date: 10/03/2008
  • Status: Active Grant
First Claim
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1. A system for determining the quality of predicted DNA base identifications, the system comprising a processor configured to:

  • receive a training data set, the training data set comprising a plurality of predicted DNA base identifications;

    define a group of subsets;

    compare the predicted DNA base identifications with actual DNA base identifications for training data within each subset of the group;

    determine a sampling characteristic for each subset of the group based on training data within the respective subset; and

    determine a quality characterization for predicted DNA base identifications within at least one of subset of the group based on the comparison and determined sampling characteristic;

    wherein the sampling characteristic comprises a confidence value comprising a binomial proportion confidence interval value; and

    detect nucleotides based on the quality characterization.

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