Tissue marker for multimodality radiographic imaging
First Claim
Patent Images
1. A radiographic marker capable of being permanently implanted in a living human or animal subject, the radiographic marker comprising:
- a fully implantable, biocompatible container formed from a nonbiodegradable solid material, the fully implantable, biocompatible container defining an internal chamber; and
a contrast agent positioned within the internal chamber, the contrast agent including a combination of a liquid and a gas, wherein the contrast agent is configured to produce a change in signal intensity in a magnetic resonance (MR) imaging modality with the radiographic marker fully implanted in the subject, wherein the nonbiodegradable solid material of the container includes a first magnetic susceptibility and the contrast agent includes a second magnetic susceptibility, wherein the nonbiodegradable solid material and the contrast agent are configured such that the first and second magnetic susceptibilities are matched so that the first magnetic susceptibility is substantially equivalent to the second magnetic susceptibility.
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Abstract
An implantable tissue marker incorporates a contrast agent scaled within a chamber in a container formed from a solid material. The contrast agent is selected to produce a change, such as an increase, in signal intensity under magnetic resonance imaging (MRI). An additional contrast agent may also be sealed within the chamber to provide visibility under another imaging modality, such as computed tomographic (CT) imaging or ultrasound imaging.
115 Citations
36 Claims
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1. A radiographic marker capable of being permanently implanted in a living human or animal subject, the radiographic marker comprising:
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a fully implantable, biocompatible container formed from a nonbiodegradable solid material, the fully implantable, biocompatible container defining an internal chamber; and a contrast agent positioned within the internal chamber, the contrast agent including a combination of a liquid and a gas, wherein the contrast agent is configured to produce a change in signal intensity in a magnetic resonance (MR) imaging modality with the radiographic marker fully implanted in the subject, wherein the nonbiodegradable solid material of the container includes a first magnetic susceptibility and the contrast agent includes a second magnetic susceptibility, wherein the nonbiodegradable solid material and the contrast agent are configured such that the first and second magnetic susceptibilities are matched so that the first magnetic susceptibility is substantially equivalent to the second magnetic susceptibility. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A radiographic marker capable of being permanently implanted in a living human or animal subject, the radiographic marker comprising:
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a fully implantable, biocompatible container formed from a nonbiodegradable solid material, the fully implantable, biocompatible container defining an internal chamber; and a contrast agent positioned within the internal chamber, the contrast agent configured to produce a change in signal intensity in a magnetic resonance (MR) imaging modality with the radiographic marker fully implanted in the subject, wherein the solid material of the fully implantable, biocompatible container includes a first magnetic susceptibility and the contrast agent includes a second magnetic susceptibility, wherein the nonbiodegradable solid material and the contrast agent are configured such that the first and second magnetic susceptibilities are matched so that the first magnetic susceptibility is substantially equivalent to the second magnetic susceptibility. - View Dependent Claims (22)
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23. A method of manufacturing a radiographic marker capable of being permanently implanted in a living human or animal subject, the method comprising:
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providing or obtaining a fully implantable, biocompatible container formed from a nonbiodegradable solid material, the fully implantable, biocompatible container defining an internal chamber; at least partially filling the internal chamber with a contrast agent including a combination of a liquid and a gas, wherein the contrast agent is configured to produce a change in signal intensity in a magnetic resonance (MR) imaging modality with the radiographic marker fully implanted in the subject, wherein the nonbiodegradable solid material of the fully implantable, biocompatible container includes a first magnetic susceptibility and the contrast agent includes a second magnetic susceptibility, wherein the nonbiodegradable solid material and the contrast agent are configured such that the first and second magnetic susceptibilities are matched so that the first magnetic susceptibility is substantially equivalent to the second magnetic susceptibility; and sealing the contrast agent within the internal chamber. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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Specification