Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject
First Claim
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1. A method for modulating an activity of brown adipose tissue of a vertebrate subject comprising:
- inducing non-shivering thermogenesis in brown adipose tissue by applying cooling to one or more brown adipose tissues of the vertebrate subject with one or more cooling elements configured to lower the temperature of the one or more brown adipose tissues and thereby induce non-shivering thermogenesis of the brown adipose tissue of the vertebrate subject, andcontrolling the one or more cooling elements with a programmable controller configured to provide instructions to the one or more cooling elements in response to information regarding one or more physiological conditions of the vertebrate subject, the one or more physiological conditions of the vertebrate subject including a plasma level of one or more metabolic analytes.
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Abstract
Devices, systems, and methods are disclosed herein for treatment of a disease, disorder, or condition in a vertebrate subject. A device is provided that includes one or more cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, and a programmable controller configured to provide instructions to the one or more cooling elements in response to information regarding one or more physiological conditions of the vertebrate subject.
114 Citations
42 Claims
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1. A method for modulating an activity of brown adipose tissue of a vertebrate subject comprising:
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inducing non-shivering thermogenesis in brown adipose tissue by applying cooling to one or more brown adipose tissues of the vertebrate subject with one or more cooling elements configured to lower the temperature of the one or more brown adipose tissues and thereby induce non-shivering thermogenesis of the brown adipose tissue of the vertebrate subject, and controlling the one or more cooling elements with a programmable controller configured to provide instructions to the one or more cooling elements in response to information regarding one or more physiological conditions of the vertebrate subject, the one or more physiological conditions of the vertebrate subject including a plasma level of one or more metabolic analytes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A method for inducing weight loss in a vertebrate subject comprising:
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inducing non-shivering thermogenesis in brown adipose tissue by applying cooling to one or more brown adipose tissues of the vertebrate subject with one or more cooling elements configured to lower the temperature of the one or more tissues and thereby inducing non-shivering thermogenesis of brown adipose tissue of the vertebrate subject, and controlling the one or more cooling elements with a programmable controller configured to provide instructions to the one or more cooling elements in response to information regarding one or more physiological conditions of the vertebrate subject, the one or more physiological conditions of the vertebrate subject including a glucose level. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A method for modulating an activity of brown adipose tissue of a vertebrate subject comprising:
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detecting a refractive index of an analyte on a surface of at least one sensor; and inducing non-shivering thermogenesis in brown adipose tissue via one or more cooling elements configured to lower the temperature of the one or more brown adipose tissues and thereby induce non-shivering thermogenesis of the brown adipose tissue of the vertebrate subject, wherein the inducing non-shivering thermogenesis via the one or more cooling elements is responsive to a change in the refractive index indicative of a target analyte level in the vertebrate subject.
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Specification