Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same
First Claim
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1. A dry composition in a solid glass form suitable for oral delivery, comprising a polysaccharide, one or more saccharides, a sugar alcohol, and a probiotic bacterium, wherein the ratio of the one or more saccharides to the sugar alcohol is 3:
- 1 to 1;
3, and wherein the sugar alcohol is selected from the group consisting of mannitol, glycerol, sorbitol, xylitol, maltitol, lactitol and isomalt.
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Abstract
The disclosure relates to a solid glass matrix of polysaccharides, monossaccharides or disaccharides in combination with polyols as delivery vehicles for preservation and post gastric administration of a probiotic. The delivery vehicle is capable of releasing the probiotic at their site of action. The present invention further includes methods of making and using the solid glass matrix delivery vehicle of the invention.
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Citations
17 Claims
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1. A dry composition in a solid glass form suitable for oral delivery, comprising a polysaccharide, one or more saccharides, a sugar alcohol, and a probiotic bacterium, wherein the ratio of the one or more saccharides to the sugar alcohol is 3:
- 1 to 1;
3, and wherein the sugar alcohol is selected from the group consisting of mannitol, glycerol, sorbitol, xylitol, maltitol, lactitol and isomalt. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
- 1 to 1;
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9. A process for producing a dry composition in a solid form suitable for oral delivery, wherein the composition comprises a polysaccharide, one or more saccharides, a sugar alcohol, and a probiotic bacterium, the process comprising:
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a) dispersing under heating conditions the polysaccharide in water; b) adding the one or more saccharides, the sugar alcohol, and the probiotic bacterium to form a slurry, wherein the ratio of the one or more saccharide to the sugar alcohol is 3;
1 to 1;
3, and wherein the sugar alcohol is selected from a group consisting of mannitol, glycerol, sorbitol, xylitol, maltitol, lactitol and isomalt;c) contacting the slurry with a Ca++ ion containing bath for a sufficient time to allow cross-linking thereby forming a gel matrix; d) maintaining the temperature of the gel matrix in a drier above the freezing temperature of the gel matrix; e) reducing the pressure during a first drying stage and maintaining the gel matrix temperature from −
10°
C. to about +40°
C. for a first period of time; andf) further reducing the pressure during a second drying stage and increasing the gel matrix temperature to between about +40°
C. to about +50°
C. for a second period of time, whereby the composition is obtained. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17)
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Specification