Functionalized surgical adhesives
First Claim
Patent Images
1. A method for bonding biological tissue comprising:
- providing a first mixture containing a plurality of reactive members of a specific binding pair, the reactive members conjugated to a first ligand wherein the first ligand is capable of binding specifically to a first receptor on a first biological tissue surface;
providing a second mixture containing a plurality of complementary reactive members of the specific binding pair, the complementary reactive members conjugated to a second ligand wherein the second ligand is capable of binding specifically to a second receptor on a second biological tissue surface;
applying the first mixture to the first biological tissue surface to bind the first ligand to the first biological tissue surface and affix the reactive members to the first biological tissue surface;
applying the second mixture to a second biological tissue surface to bind the second ligand to the second biological tissue surface and affix the complementary reactive members to the second biological tissue surface;
wherein the members of the specific binding pair are alkynes and azides, and contacting the reactive members affixed to the first biological tissue surface with the complimentary reactive members affixed to the second biological tissue surface to form covalent bonds between the reactive members and the complementary reactive members, thus adhering the first biological tissue surface to the second biological tissue surface.
1 Assignment
0 Petitions
Accused Products
Abstract
A bioadherent composition includes a first mixture containing a plurality of reactive members of a specific binding pair, said reactive members being bound to a ligand capable of binding a receptor on biological tissue, and a second mixture containing a plurality of complementary reactive members of the specific binding pair, said complementary reactive members being bound to a ligand capable of binding a receptor on biological tissue, said reactive members capable of forming covalent bonds with said complementary reactive members via a reaction selected from Huisgen cycloaddition reactions, Diels-Alder reactions, and/or thiol-alkene reactions. A method for bonding biological tissue involves utilizing the bioadherent composition.
-
Citations
13 Claims
-
1. A method for bonding biological tissue comprising:
- providing a first mixture containing a plurality of reactive members of a specific binding pair, the reactive members conjugated to a first ligand wherein the first ligand is capable of binding specifically to a first receptor on a first biological tissue surface;
providing a second mixture containing a plurality of complementary reactive members of the specific binding pair, the complementary reactive members conjugated to a second ligand wherein the second ligand is capable of binding specifically to a second receptor on a second biological tissue surface;
applying the first mixture to the first biological tissue surface to bind the first ligand to the first biological tissue surface and affix the reactive members to the first biological tissue surface;
applying the second mixture to a second biological tissue surface to bind the second ligand to the second biological tissue surface and affix the complementary reactive members to the second biological tissue surface;
wherein the members of the specific binding pair are alkynes and azides, and contacting the reactive members affixed to the first biological tissue surface with the complimentary reactive members affixed to the second biological tissue surface to form covalent bonds between the reactive members and the complementary reactive members, thus adhering the first biological tissue surface to the second biological tissue surface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
- providing a first mixture containing a plurality of reactive members of a specific binding pair, the reactive members conjugated to a first ligand wherein the first ligand is capable of binding specifically to a first receptor on a first biological tissue surface;
Specification
-
- Resources
Litigation Campaign Assessment
Thank you for your request. You will receive a custom alert email when the Litigation Campaign Assessment is available.
×
-
Current AssigneeSofradim Production
-
Original AssigneeSofradim Production
-
InventorsLadet, Sebastien
-
Primary Examiner(s)Haq, Shafiqul
-
Application NumberUS12/708,776Publication NumberTime in Patent Office1,838 DaysField of SearchUS Class Current424/133.1CPC Class CodesA61L 24/001 Use of materials characteri...A61L 24/04 containing macromolecular m...A61L 24/10 Polypeptides; Proteins A61L...A61L 24/108 Specific proteins or polype...A61P 17/02 for treating wounds, ulcers...
