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Nanoformulation of vitamin D derivatives and/or vitamin D metabolites

  • US 8,968,790 B2
  • Filed: 12/06/2012
  • Issued: 03/03/2015
  • Est. Priority Date: 12/09/2011
  • Status: Active Grant
First Claim
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1. A nanoformulation, comprising:

  • nanoparticles, each nanoparticle comprising a modified chitosan polymer encapsulating at least one vitamin D derivative, at least one vitamin D metabolite, or combinations thereof,wherein the modified chitosan polymer comprises chitosan covalently linked to at least one entity selected from the group consisting of fatty acids, amino acids, deoxycholate, alginate, arginine-alginate, collagen, collagen-hydroxyapatite, poly(lactic-co-glycolic acid) (PLGA), and combinations thereof,wherein the modified chitosan polymer is hydrophobic, and wherein the chitosan comprises a molecular weight in a range of 5 to 150 kilo Daltons.

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