In vivo micro-invasive investigation device including a metal guide
First Claim
1. An analysis device comprising:
- a system for at least one of a micro-invasive and a micro-sampling investigation of a substrate, said system comprising at least one metal guide including;
a first extremity having a surface structured to define at least a series of wells to which are directly coupled at least one reactive group specific to said substrate, said first extremity being perforating, anda second extremity intended for handling said metal guide.
1 Assignment
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Accused Products
Abstract
The invention relates to an analysis device, wherein said system includes at least one metal guide at one end of which is provided at least one series of pits to which are directly coupled reagents specific to a substrate, said end being a perforating one, while the other end is intended for controlling said guide and is optionally associated with a suction system. The guide may be inserted into a protection system that is removable at the level of the functionalized end, up to the micro-analysis and/or micro-sampling site, and/or into a medical instrument having an inner channel in which said guide may slide. The present invention also relates to the use of such a device for making a tool for diagnosing cancer, an inflammation, an infection, a neurodegenerative disease or a graft rejection in a patient, preferably by transparietal delivery. The invention further relates to a method for the ex vivo analysis of a substrate using such a device.
6 Citations
26 Claims
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1. An analysis device comprising:
a system for at least one of a micro-invasive and a micro-sampling investigation of a substrate, said system comprising at least one metal guide including; a first extremity having a surface structured to define at least a series of wells to which are directly coupled at least one reactive group specific to said substrate, said first extremity being perforating, and a second extremity intended for handling said metal guide. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A tool intended for diagnosing a cancer, an inflammation, an infection, a graft rejection or a neurodegenerative pathology such as Alzheimer'"'"'s disease, Parkinson'"'"'s disease or an amyotrophic lateral sclerosis, the tool comprising:
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an endoscope, a flexible catheter configured for insertion into the endoscope, and at least one metal guide configured for insertion into the flexible catheter, each metal slide comprising; a first extremity having a surface structured to define at least a series of wells to which are directly coupled at least one reactive group specific to said substrate, said first extremity being perforating, and a second extremity intended for handling said metal guide. - View Dependent Claims (17, 18, 19, 20)
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21. A method for detecting ex-vivo a substrate existing in a tissue or an organ, comprising:
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a) providing a device comprising a system for a micro-invasive and/or micro-sampling investigation of a substrate, said system comprising at least one metal guide including; a first extremity having a surface defining at least a series of wells to which are directly coupled at least one reactive group specific to said substrate, said extremity being perforating, and a second extremity intended for handling said metal guide; b) incubating the functionalised first extremity of the device with a solution comprising at least one detection agent specific to said substrate when said first extremity is in contact with said tissue or organ to be examined; and c) detecting said substrate. - View Dependent Claims (22, 23, 24, 25, 26)
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Specification